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- W2015326507 abstract "We investigated the effects of a calcium antagonist, efonidipine, which was reported to dilate not only afferent arterioles but also efferent arterioles, on progression of renal failure in salt-loaded partially nephrectomized spontaneously hypertensive rats (SHR). Forty-four SHR's with 5 of 6 nephrectomy were divided into four groups: group 1 as control (n=20); group 2, efonidipine-treated (n=8); group 3, enalapril-treated (n=8); and group 4, nifedipine-treated (n=8). The rats were given these drugs and a high-salt diet (5% NaCl) for 8 weeks. During the experiment, systolic blood pressure (SBP) and daily urinary protein excretion were measured eveiy 2 weeks. At the end of the study. seniin creatinine was deteimined, and renal tissues were obtained for light microscopic examination. SBI was markedly reduced by 8-week antihypertensive treatment. (control, 267±7 mmHg: efonidipine, 181 ± 7 mmHg; enalapril, 200±12 mmHg; nifedipine, 184±6 mmHg). Glomerular sclerosis developed markedly in the control group, but was partially prevented in all treated groups. Similarly, urinary protein excretion (UPE) was suppressed by efonidipine (180±16 mg/day) and enalapril (180±16 mg/day vs. 301±28 mg/day for control). In contrast, nifedipine failed to prevent the increase in urinaiy protein excretion (258±22 mg/day). In conclusion, efonidipine attenuates SBP increase and ameliorates glomerular injuty as well as nifedipine and enalapril. Furthermore, beneficial effects of efonidipine, but not nifedipine, on proteinuria suggest that different mechanisms mediate the improvement of proteinuria; one possible mechanism could be efferent arteriolar dilation, not reported in nifedipine." @default.
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- W2015326507 date "1998-01-01" @default.
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- W2015326507 title "Renal Protective Effects of Efonidipine in Partially Nephrectomized Spontaneously Hypertensive Rats" @default.
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- W2015326507 doi "https://doi.org/10.3109/10641969809052123" @default.
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