FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015328304> ?p ?o ?g. }

• W2015328304 endingPage "8865" @default.
• W2015328304 startingPage "8852" @default.
• W2015328304 abstract "Neuronal migration is an essential process for the development of the cerebral cortex. We have previously shown that LKB1, an evolutionally conserved polarity kinase, plays a critical role in neuronal migration in the developing neocortex. Here we show that LKB1 mediates Ser9 phosphorylation of GSK3beta to inactivate the kinase at the leading process tip of migrating neurons in the developing neocortex. This enables the microtubule plus-end binding protein adenomatous polyposis coli (APC) to localize at the distal ends of microtubules in the tip, thereby stabilizing microtubules near the leading edge. We also show that LKB1 activity, Ser9 phosphorylation of GSK3beta, and APC binding to the distal ends of microtubules are required for the microtubule stabilization in the leading process tip, centrosomal forward movement, and neuronal migration. These findings suggest that LKB1-induced spatial control of GSK3beta and APC at the leading process tip mediates the stabilization of microtubules within the tip and is critical for centrosomal forward movement and neuronal migration in the developing neocortex." @default.
• W2015328304 created "2016-06-24" @default.
• W2015328304 creator A5028537713 @default.
• W2015328304 creator A5042505089 @default.
• W2015328304 date "2010-06-30" @default.
• W2015328304 modified "2023-10-01" @default.
• W2015328304 title "LKB1-Mediated Spatial Control of GSK3 and Adenomatous Polyposis Coli Contributes to Centrosomal Forward Movement and Neuronal Migration in the Developing Neocortex" @default.
• W2015328304 cites W1523601423 @default.
• W2015328304 cites W1546151374 @default.
• W2015328304 cites W1809606297 @default.
• W2015328304 cites W1963967855 @default.
• W2015328304 cites W1965256428 @default.
• W2015328304 cites W1967921405 @default.
• W2015328304 cites W1969857864 @default.
• W2015328304 cites W1970302470 @default.
• W2015328304 cites W1974655756 @default.
• W2015328304 cites W1975079427 @default.
• W2015328304 cites W1980979311 @default.
• W2015328304 cites W1984374880 @default.
• W2015328304 cites W1993145412 @default.
• W2015328304 cites W1993155860 @default.
• W2015328304 cites W1996982933 @default.
• W2015328304 cites W1997950260 @default.
• W2015328304 cites W2002858128 @default.
• W2015328304 cites W2002897207 @default.
• W2015328304 cites W2005900617 @default.
• W2015328304 cites W2006628753 @default.
• W2015328304 cites W2015961658 @default.
• W2015328304 cites W2017715649 @default.
• W2015328304 cites W2050642338 @default.
• W2015328304 cites W2050893705 @default.
• W2015328304 cites W2050998289 @default.
• W2015328304 cites W2056986410 @default.
• W2015328304 cites W2058549524 @default.
• W2015328304 cites W2061414672 @default.
• W2015328304 cites W2063120457 @default.
• W2015328304 cites W2066888192 @default.
• W2015328304 cites W2074741279 @default.
• W2015328304 cites W2082387343 @default.
• W2015328304 cites W2083436950 @default.
• W2015328304 cites W2084080552 @default.
• W2015328304 cites W2085655013 @default.
• W2015328304 cites W2087084624 @default.
• W2015328304 cites W2088680750 @default.
• W2015328304 cites W2092619797 @default.
• W2015328304 cites W2094228287 @default.
• W2015328304 cites W2095435423 @default.
• W2015328304 cites W2097899984 @default.
• W2015328304 cites W2106488950 @default.
• W2015328304 cites W2138319716 @default.
• W2015328304 cites W2143943557 @default.
• W2015328304 cites W2153779995 @default.
• W2015328304 cites W2161930851 @default.
• W2015328304 doi "https://doi.org/10.1523/jneurosci.6140-09.2010" @default.
• W2015328304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6632896" @default.
• W2015328304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20592207" @default.
• W2015328304 hasPublicationYear "2010" @default.
• W2015328304 type Work @default.
• W2015328304 sameAs 2015328304 @default.
• W2015328304 citedByCount "56" @default.
• W2015328304 countsByYear W20153283042012 @default.
• W2015328304 countsByYear W20153283042013 @default.
• W2015328304 countsByYear W20153283042014 @default.
• W2015328304 countsByYear W20153283042015 @default.
• W2015328304 countsByYear W20153283042016 @default.
• W2015328304 countsByYear W20153283042017 @default.
• W2015328304 countsByYear W20153283042018 @default.
• W2015328304 countsByYear W20153283042019 @default.
• W2015328304 countsByYear W20153283042020 @default.
• W2015328304 countsByYear W20153283042021 @default.
• W2015328304 countsByYear W20153283042022 @default.
• W2015328304 countsByYear W20153283042023 @default.
• W2015328304 crossrefType "journal-article" @default.
• W2015328304 hasAuthorship W2015328304A5028537713 @default.
• W2015328304 hasAuthorship W2015328304A5042505089 @default.
• W2015328304 hasBestOaLocation W20153283041 @default.
• W2015328304 hasConcept C169760540 @default.
• W2015328304 hasConcept C20418707 @default.
• W2015328304 hasConcept C2777222312 @default.
• W2015328304 hasConcept C86803240 @default.
• W2015328304 hasConcept C95444343 @default.
• W2015328304 hasConceptScore W2015328304C169760540 @default.
• W2015328304 hasConceptScore W2015328304C20418707 @default.
• W2015328304 hasConceptScore W2015328304C2777222312 @default.
• W2015328304 hasConceptScore W2015328304C86803240 @default.
• W2015328304 hasConceptScore W2015328304C95444343 @default.
• W2015328304 hasIssue "26" @default.
• W2015328304 hasLocation W20153283041 @default.
• W2015328304 hasLocation W20153283042 @default.
• W2015328304 hasLocation W20153283043 @default.
• W2015328304 hasLocation W20153283044 @default.
• W2015328304 hasOpenAccess W2015328304 @default.
• W2015328304 hasPrimaryLocation W20153283041 @default.
• W2015328304 hasRelatedWork W1987038781 @default.
• W2015328304 hasRelatedWork W2019528658 @default.
• W2015328304 hasRelatedWork W2051754529 @default.
• W2015328304 hasRelatedWork W2071596650 @default.
• W2015328304 hasRelatedWork W2102146626 @default.

• next