FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015330161> ?p ?o ?g. }

• W2015330161 endingPage "3553" @default.
• W2015330161 startingPage "3545" @default.
• W2015330161 abstract "The ability of cells to respond and repair DNA damage is fundamental for the maintenance of genomic integrity. Ex vivo culturing of surgery-derived human tissues has provided a significant advancement to assess DNA damage response (DDR) in the context of normal cytoarchitecture in a non-proliferating tissue. Here, we assess the dependency of prostate epithelium DDR on ATM and DNA-PKcs, the major kinases responsible for damage detection and repair by nonhomologous end-joining (NHEJ), respectively. DNA damage was caused by ionizing radiation (IR) and cytotoxic drugs, cultured tissues were treated with ATM and DNA-PK inhibitors, and DDR was assessed by phosphorylation of ATM and its targets H2AX and KAP1, a heterochromatin binding protein. Phosphorylation of H2AX and KAP1 was fast, transient and fully dependent on ATM, but these responses were moderate in luminal cells. In contrast, DNA-PKcs was phosphorylated in both luminal and basal cells, suggesting that DNA-PK-dependent repair was also activated in the luminal cells despite the diminished H2AX and KAP1 responses. These results indicate that prostate epithelial cell types have constitutively dissimilar responses to DNA damage. We correlate the altered damage response to the differential chromatin state of the cells. These findings are relevant in understanding how the epithelium senses and responds to DNA damage." @default.
• W2015330161 created "2016-06-24" @default.
• W2015330161 creator A5014243227 @default.
• W2015330161 creator A5028508240 @default.
• W2015330161 creator A5054382474 @default.
• W2015330161 creator A5057451470 @default.
• W2015330161 creator A5067102328 @default.
• W2015330161 creator A5070855130 @default.
• W2015330161 creator A5081198623 @default.
• W2015330161 creator A5083333223 @default.
• W2015330161 creator A5087493207 @default.
• W2015330161 date "2011-10-15" @default.
• W2015330161 modified "2023-10-03" @default.
• W2015330161 title "Differential epithelium DNA damage response to ATM and DNA-PK pathway inhibition in human prostate tissue culture" @default.
• W2015330161 cites W104404459 @default.
• W2015330161 cites W1538419182 @default.
• W2015330161 cites W1964303708 @default.
• W2015330161 cites W1968182774 @default.
• W2015330161 cites W1971393461 @default.
• W2015330161 cites W1972518056 @default.
• W2015330161 cites W1985775217 @default.
• W2015330161 cites W1990374273 @default.
• W2015330161 cites W1996110032 @default.
• W2015330161 cites W2000580034 @default.
• W2015330161 cites W2005939114 @default.
• W2015330161 cites W2007369689 @default.
• W2015330161 cites W2014766736 @default.
• W2015330161 cites W2015925058 @default.
• W2015330161 cites W2024781225 @default.
• W2015330161 cites W2027630134 @default.
• W2015330161 cites W2028391733 @default.
• W2015330161 cites W2029065442 @default.
• W2015330161 cites W2031203839 @default.
• W2015330161 cites W2032170380 @default.
• W2015330161 cites W2033172828 @default.
• W2015330161 cites W2036643295 @default.
• W2015330161 cites W2041656651 @default.
• W2015330161 cites W2043776284 @default.
• W2015330161 cites W2044721366 @default.
• W2015330161 cites W2051193631 @default.
• W2015330161 cites W2064117760 @default.
• W2015330161 cites W2070582215 @default.
• W2015330161 cites W2074483662 @default.
• W2015330161 cites W2075490190 @default.
• W2015330161 cites W2075758387 @default.
• W2015330161 cites W2077436902 @default.
• W2015330161 cites W2086556990 @default.
• W2015330161 cites W2090571513 @default.
• W2015330161 cites W2091136099 @default.
• W2015330161 cites W2091884937 @default.
• W2015330161 cites W2096136751 @default.
• W2015330161 cites W2110817748 @default.
• W2015330161 cites W2132396299 @default.
• W2015330161 cites W2137935085 @default.
• W2015330161 cites W2142201907 @default.
• W2015330161 cites W2145200068 @default.
• W2015330161 cites W2148676049 @default.
• W2015330161 cites W2161489869 @default.
• W2015330161 cites W2170776600 @default.
• W2015330161 cites W88099035 @default.
• W2015330161 doi "https://doi.org/10.4161/cc.10.20.17841" @default.
• W2015330161 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3356835" @default.
• W2015330161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22030624" @default.
• W2015330161 hasPublicationYear "2011" @default.
• W2015330161 type Work @default.
• W2015330161 sameAs 2015330161 @default.
• W2015330161 citedByCount "20" @default.
• W2015330161 countsByYear W20153301612012 @default.
• W2015330161 countsByYear W20153301612013 @default.
• W2015330161 countsByYear W20153301612014 @default.
• W2015330161 countsByYear W20153301612016 @default.
• W2015330161 countsByYear W20153301612017 @default.
• W2015330161 countsByYear W20153301612018 @default.
• W2015330161 countsByYear W20153301612019 @default.
• W2015330161 countsByYear W20153301612020 @default.
• W2015330161 crossrefType "journal-article" @default.
• W2015330161 hasAuthorship W2015330161A5014243227 @default.
• W2015330161 hasAuthorship W2015330161A5028508240 @default.
• W2015330161 hasAuthorship W2015330161A5054382474 @default.
• W2015330161 hasAuthorship W2015330161A5057451470 @default.
• W2015330161 hasAuthorship W2015330161A5067102328 @default.
• W2015330161 hasAuthorship W2015330161A5070855130 @default.
• W2015330161 hasAuthorship W2015330161A5081198623 @default.
• W2015330161 hasAuthorship W2015330161A5083333223 @default.
• W2015330161 hasAuthorship W2015330161A5087493207 @default.
• W2015330161 hasBestOaLocation W20153301611 @default.
• W2015330161 hasConcept C134935766 @default.
• W2015330161 hasConcept C143425029 @default.
• W2015330161 hasConcept C151730666 @default.
• W2015330161 hasConcept C153911025 @default.
• W2015330161 hasConcept C2779343474 @default.
• W2015330161 hasConcept C502942594 @default.
• W2015330161 hasConcept C54355233 @default.
• W2015330161 hasConcept C552990157 @default.
• W2015330161 hasConcept C64927066 @default.
• W2015330161 hasConcept C83640560 @default.
• W2015330161 hasConcept C86803240 @default.
• W2015330161 hasConcept C95444343 @default.

• next