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• W2015330660 endingPage "83" @default.
• W2015330660 startingPage "64" @default.
• W2015330660 abstract "Adenosine has long been considered an endogenous anti-epileptic compound. This concept was based on the widespread distribution of adenosine A1 receptors (A1R), which are mostly located in excitatory synapses; here, A1R in- hibit glutamate release, decrease glutamatergic responsiveness and hyperpolarise neurons. However, the combined obser- vation that synaptic A1R undergo desensitisation in chronic noxious situations whereas the activation of A1R still prevents seizure activity suggests that the A1R anti-epileptic action may involve non-synaptic mechanisms. Two alternative mechanisms can be considered to explain the ability of A1R to control seizure activity and resulting neurodegeneration: 1) the possible role of A1R-mediated control of metabolism; 2) the A1R-mediated preconditioning involving a coordinated control of neuron-glia communication. However, purinergic modulation of seizure activity is likely to involve other sys- tems apart from A1R. Thus, the blockade of adenosine A2A receptors (A2AR), which density increases in animal models of epilepsy, can attenuate seizure activity and prevent seizure-induced neurodegeneration. Furthermore, ATP, which is the main source of the endogenous adenosine activating A2AR, also act as a general danger signal and may also directly con- trol seizure activity through P2 receptors (P2R). Therefore, the purinergic control of epilepsy may actually involve differ- ent parallel signalling arms, some beneficial and others deleterious, probably acting at different sites (in epileptic foci and in their neighbourhood) and at different times. It is likely that combined targeting of different purinergic receptors may be the most efficacious way to control seizure activity, its spreading and the resulting neurodegeneration." @default.
• W2015330660 created "2016-06-24" @default.
• W2015330660 creator A5009553869 @default.
• W2015330660 creator A5039106439 @default.
• W2015330660 creator A5058483077 @default.
• W2015330660 date "2010-01-01" @default.
• W2015330660 modified "2023-09-27" @default.
• W2015330660 title "Role of The Purinergic Neuromodulation System in Epilepsy" @default.
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