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• W2015330897 abstract "The aim of this study was to review the management of children with Wilms' tumour who have intracardiac extension.Data were collected from patient notes regarding presentation, operative details, and outcome.From 1984 through 2011, 264 children with Wilms' tumour were treated at our hospital. Nine (3.4%) had cavo-atrial extension of the tumour thrombus. The thrombus extended into the right ventricle in two children and involved the hepatic veins in both, and also two others. Pre-operative chemotherapy was administered in eight children with complete regression of the intra-cardiac tumour thrombus in two cases. One child died preoperatively of septicaemia and respiratory failure after two doses of chemotherapy. Six children with intra-cardiac tumour were operated on under cardiopulmonary bypass (CPB) with deep hypothermia and circulatory arrest (DHCA). The mean ischemic time was 30 min. There was one peri-operative death in a child with hepatic vein involvement and Budd-Chiari syndrome. All others made a good postoperative recovery. All tumours were favourable histology. To date four children are still alive and disease free. Three children have died as a result of pulmonary metastases.Intracardiac extension of Wilms' tumour is rare, and the management is technically challenging. Pre-operative chemotherapy is effective. CPB and DHCA for excision of the cavo-atrial tumour thrombus may be necessary. Distant metastatic disease is common and determines long term prognosis. Hepatic vein extension complicates surgery and remains challenging." @default.
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• W2015330897 date "2013-02-01" @default.
• W2015330897 modified "2023-09-24" @default.
• W2015330897 title "Management of nine cases of Wilms’ tumour with intracardiac extension — a single centre experience" @default.
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• W2015330897 doi "https://doi.org/10.1016/j.jpedsurg.2012.11.024" @default.
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