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• W2015332296 abstract "With countless biological details emerging from cancer experiments, there is a growing need for minimal mathematical models which simultaneously advance our understanding of single tumors and metastasis, provide patient-personalized predictions, whilst avoiding excessive hard-to-measure input parameters which complicate simulation, analysis and interpretation. Here we present a model built around a co-evolving resource network and cell population, yielding good agreement with primary tumors in a murine mammary cell line EMT6-HER2 model in BALB/c mice and with clinical metastasis data. Seeding data about the tumor and its vasculature from in vivo images, our model predicts corridors of future tumor growth behavior and intervention response. A scaling relation enables the estimation of a tumor's most likely evolution and pinpoints specific target sites to control growth. Our findings suggest that the clinically separate phenomena of individual tumor growth and metastasis can be viewed as mathematical copies of each other differentiated only by network structure." @default.
• W2015332296 created "2016-06-24" @default.
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• W2015332296 date "2011-07-06" @default.
• W2015332296 modified "2023-09-26" @default.
• W2015332296 title "Model for in vivo progression of tumors based on co-evolving cell population and vasculature" @default.
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• W2015332296 doi "https://doi.org/10.1038/srep00031" @default.
• W2015332296 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3216518" @default.
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• W2015332296 hasPublicationYear "2011" @default.
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