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• W2015332512 endingPage "36" @default.
• W2015332512 startingPage "29" @default.
• W2015332512 abstract "The serum- and glucocorticoid-inducible kinase 1 (SGK1) is genomically upregulated by cell stress including energy depletion and hyperosmotic shock as well as a variety of hormones including glucocorticoids, mineralocorticoids and TGFβ. SGK1 is activated by insulin, growth factors and oxidative stress via phosphatidylinositide-3-kinase, 3-phosphoinositide-dependent kinase PDK1 and mTOR. SGK1 is a powerful stimulator of Na(+)/K(+)-ATPase, carriers (e.g., NCC, NKCC, NHE1, NHE3, SGLT1, several amino acid transporters) and ion channels (e.g., ENaC, SCN5A, TRPV4-6, ORAI1/STIM1, ROMK, KCNE1/KCNQ1, GluR6, CFTR). Mechanisms employed by SGK1 in transport regulation include direct phosphorylation of target transport proteins, phosphorylation and thus activation of other transport regulating kinases, stabilization of membrane proteins by phosphorylation and thus inactivation of the ubiquitin ligase NEDD4-2, as well as stimulation of transport protein expression by upregulation transcription factors (e.g., nuclear factor kappa-B [NFκB]) and by fostering of protein translation. SGK1 sensitivity of pump, carrier and channel activities participate in the regulation of epithelial transport, cardiac and neuronal excitability, degranulation, platelet function, migration, cell proliferation and apoptosis. SGK1-sensitive functions do not require the presence of SGK1 but are markedly upregulated by SGK1. Accordingly, the phenotype of SGK1 knockout mice is mild. The mice are, however, less sensitive to excessive activation of transport by glucocorticoids, mineralocorticoids, insulin and inflammation. Moreover, excessive SGK1 activity contributes to the pathophysiology of hypertension, obesity, diabetes, thrombosis, stroke, inflammation, autoimmune disease, fibrosis and tumor growth." @default.
• W2015332512 created "2016-06-24" @default.
• W2015332512 creator A5004202808 @default.
• W2015332512 creator A5032683795 @default.
• W2015332512 creator A5084208566 @default.
• W2015332512 date "2014-01-14" @default.
• W2015332512 modified "2023-10-14" @default.
• W2015332512 title "Regulation of transport across cell membranes by the serum- and glucocorticoid-inducible kinase SGK1" @default.
• W2015332512 cites W1251940471 @default.
• W2015332512 cites W1560014945 @default.
• W2015332512 cites W1711415098 @default.
• W2015332512 cites W1813428079 @default.
• W2015332512 cites W1963619089 @default.
• W2015332512 cites W1970458900 @default.
• W2015332512 cites W1971721011 @default.
• W2015332512 cites W1972771992 @default.
• W2015332512 cites W1974945671 @default.
• W2015332512 cites W1976237854 @default.
• W2015332512 cites W1978411089 @default.
• W2015332512 cites W1982549756 @default.
• W2015332512 cites W1983411366 @default.
• W2015332512 cites W1984261845 @default.
• W2015332512 cites W1984345669 @default.
• W2015332512 cites W1987172383 @default.
• W2015332512 cites W1993712825 @default.
• W2015332512 cites W1996101695 @default.
• W2015332512 cites W1996956897 @default.
• W2015332512 cites W1997221164 @default.
• W2015332512 cites W1999916995 @default.
• W2015332512 cites W2000487504 @default.
• W2015332512 cites W2000630777 @default.
• W2015332512 cites W2001960543 @default.
• W2015332512 cites W2005789117 @default.
• W2015332512 cites W2010944978 @default.
• W2015332512 cites W2011137086 @default.
• W2015332512 cites W2015235010 @default.
• W2015332512 cites W2015517299 @default.
• W2015332512 cites W2017815001 @default.
• W2015332512 cites W2021005448 @default.
• W2015332512 cites W2025894991 @default.
• W2015332512 cites W2027307327 @default.
• W2015332512 cites W2030984190 @default.
• W2015332512 cites W2031194730 @default.
• W2015332512 cites W2035708746 @default.
• W2015332512 cites W2037823235 @default.
• W2015332512 cites W2038245749 @default.
• W2015332512 cites W2038251105 @default.
• W2015332512 cites W2038879576 @default.
• W2015332512 cites W2038894034 @default.
• W2015332512 cites W2039153316 @default.
• W2015332512 cites W2050822876 @default.
• W2015332512 cites W2056234074 @default.
• W2015332512 cites W2057034300 @default.
• W2015332512 cites W2063455378 @default.
• W2015332512 cites W2066096361 @default.
• W2015332512 cites W2067889812 @default.
• W2015332512 cites W2067976936 @default.
• W2015332512 cites W2074467476 @default.
• W2015332512 cites W2074594979 @default.
• W2015332512 cites W2074631636 @default.
• W2015332512 cites W2074732589 @default.
• W2015332512 cites W2075971181 @default.
• W2015332512 cites W2079036300 @default.
• W2015332512 cites W2083069365 @default.
• W2015332512 cites W2083964872 @default.
• W2015332512 cites W2084324443 @default.
• W2015332512 cites W2084901230 @default.
• W2015332512 cites W2085736792 @default.
• W2015332512 cites W2087067156 @default.
• W2015332512 cites W2087312127 @default.
• W2015332512 cites W2092097309 @default.
• W2015332512 cites W2100509778 @default.
• W2015332512 cites W2104207586 @default.
• W2015332512 cites W2111123535 @default.
• W2015332512 cites W2111952904 @default.
• W2015332512 cites W2112551775 @default.
• W2015332512 cites W2112837750 @default.
• W2015332512 cites W2119489521 @default.
• W2015332512 cites W2120301246 @default.
• W2015332512 cites W2122221794 @default.
• W2015332512 cites W2123871864 @default.
• W2015332512 cites W2124730658 @default.
• W2015332512 cites W2126405504 @default.
• W2015332512 cites W2132651910 @default.
• W2015332512 cites W2137652355 @default.
• W2015332512 cites W2141191708 @default.
• W2015332512 cites W2147601976 @default.
• W2015332512 cites W2148382170 @default.
• W2015332512 cites W2150397663 @default.
• W2015332512 cites W2150548551 @default.
• W2015332512 cites W2151002056 @default.
• W2015332512 cites W2154911070 @default.
• W2015332512 cites W2155645192 @default.
• W2015332512 cites W2158969044 @default.
• W2015332512 cites W2159820745 @default.
• W2015332512 cites W2163028543 @default.
• W2015332512 cites W2164364619 @default.
• W2015332512 cites W2165291356 @default.

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