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- W2015334573 abstract "Abstract Bioactive lipids serve as intracellular and extracellular mediators in cell signaling in normal and pathological conditions. Here we describe that an important regulator of some of these lipids, the lipid phosphate phosphatase‐3 (LPP3), is abundantly expressed in specific plasma membrane domains of Bergmann glia (BG), a specialized type of astrocyte with key roles in cerebellum development and physiology. Mice selectively lacking expression of LPP3/ Ppap2b in the nervous system are viable and fertile but exhibit defects in postnatal cerebellum development and modifications in the cytoarchitecture and arrangement of BG with a mild non‐progressive motor coordination defect. Lipid and gene profiling studies in combination with pharmacological treatments suggest that most of these effects are associated with alterations in sphingosine‐1‐phosphate (S1P) metabolism and signaling. Altogether our data indicate that LPP3 participates in several aspects of neuron‐glia communication required for proper cerebellum development. © 2011 Wiley‐Liss, Inc." @default.
- W2015334573 created "2016-06-24" @default.
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- W2015334573 date "2011-01-06" @default.
- W2015334573 modified "2023-10-17" @default.
- W2015334573 title "Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development" @default.
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- W2015334573 doi "https://doi.org/10.1002/glia.21126" @default.
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