FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015334764> ?p ?o ?g. }

• W2015334764 endingPage "597" @default.
• W2015334764 startingPage "589" @default.
• W2015334764 abstract "Background: The effector function of eosinophils involves their release of toxic granule proteins, reactive oxygen species, cytokines, and lipid mediators. Murine studies have demonstrated that eosinophils can also enhance T cell function. Whether human eosinophils, in particular, airway eosinophils, have similar immunoregulatory activity has not been fully investigated. The aim of this study was to determine whether human blood and airway eosinophils can contribute to Th1 and Th2 cytokine generation from CD4+ T cells stimulated with superantigen. Methods: Eosinophils were obtained from blood or bronchoalveolar lavage fluid 48 h after segmental allergen bronchoprovocation. Purified eosinophils were co‐cultured with autologous CD4+ blood T cells in the presence of staphylococcal enterotoxin B (SEB). Cytokine levels in the supernatant fluid were determined by enzyme‐linked immunosorbent assay (ELISA). Eosinophil expression of major histocompatibility complex (MHC) class II and co‐stimulatory molecules was assessed by flow cytometry before culture, 24 h after granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) stimulation, and 24 h after co‐culture with CD4+ T cells and SEB. Results: Interleukin (IL)‐5, IL‐13, and interferon (IFN)‐ γ generation increased when CD4+ T cells were co‐cultured with either blood or airway eosinophils in the presence of SEB. The ability of eosinophils to enhance cytokine generation was independent of their source (blood vs airway), activation by GM‐CSF, or detectable expression of human leukocyte antigen (HLA)‐DR, CD80, or CD86. Conclusion: Our data demonstrate that SEB‐induced generation of Th1 and Th2 cytokines is increased in the presence of human blood and airway eosinophils. Thus, eosinophils can have an immunoregulatory function in pathogen‐associated allergic diseases such as atopic dermatitis, chronic sinusitis, and asthma exacerbations." @default.
• W2015334764 created "2016-06-24" @default.
• W2015334764 creator A5005205857 @default.
• W2015334764 creator A5007745480 @default.
• W2015334764 creator A5032104300 @default.
• W2015334764 creator A5039796140 @default.
• W2015334764 creator A5044980958 @default.
• W2015334764 creator A5046236328 @default.
• W2015334764 date "2006-03-30" @default.
• W2015334764 modified "2023-10-17" @default.
• W2015334764 title "Human airway and peripheral blood eosinophils enhance Th1 and Th2 cytokine secretion" @default.
• W2015334764 cites W1521999644 @default.
• W2015334764 cites W1585243780 @default.
• W2015334764 cites W1600922886 @default.
• W2015334764 cites W1609688492 @default.
• W2015334764 cites W1672277059 @default.
• W2015334764 cites W1721686426 @default.
• W2015334764 cites W1879498419 @default.
• W2015334764 cites W1966321620 @default.
• W2015334764 cites W1968069624 @default.
• W2015334764 cites W1972993283 @default.
• W2015334764 cites W1978563572 @default.
• W2015334764 cites W1986249624 @default.
• W2015334764 cites W1990075382 @default.
• W2015334764 cites W1998174064 @default.
• W2015334764 cites W2008251353 @default.
• W2015334764 cites W2014191094 @default.
• W2015334764 cites W2023308742 @default.
• W2015334764 cites W2028407984 @default.
• W2015334764 cites W2032052491 @default.
• W2015334764 cites W2044733111 @default.
• W2015334764 cites W2048279295 @default.
• W2015334764 cites W2053082547 @default.
• W2015334764 cites W2060791065 @default.
• W2015334764 cites W2072921779 @default.
• W2015334764 cites W2073934822 @default.
• W2015334764 cites W2085241425 @default.
• W2015334764 cites W2099027783 @default.
• W2015334764 cites W2104654172 @default.
• W2015334764 cites W2129209196 @default.
• W2015334764 cites W2143653962 @default.
• W2015334764 cites W2156211073 @default.
• W2015334764 cites W2157340183 @default.
• W2015334764 cites W2168741114 @default.
• W2015334764 cites W2171914901 @default.
• W2015334764 cites W2409243507 @default.
• W2015334764 doi "https://doi.org/10.1111/j.1398-9995.2006.01060.x" @default.
• W2015334764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16629789" @default.
• W2015334764 hasPublicationYear "2006" @default.
• W2015334764 type Work @default.
• W2015334764 sameAs 2015334764 @default.
• W2015334764 citedByCount "57" @default.
• W2015334764 countsByYear W20153347642012 @default.
• W2015334764 countsByYear W20153347642013 @default.
• W2015334764 countsByYear W20153347642014 @default.
• W2015334764 countsByYear W20153347642015 @default.
• W2015334764 countsByYear W20153347642016 @default.
• W2015334764 countsByYear W20153347642017 @default.
• W2015334764 countsByYear W20153347642018 @default.
• W2015334764 countsByYear W20153347642019 @default.
• W2015334764 countsByYear W20153347642020 @default.
• W2015334764 countsByYear W20153347642021 @default.
• W2015334764 countsByYear W20153347642022 @default.
• W2015334764 countsByYear W20153347642023 @default.
• W2015334764 crossrefType "journal-article" @default.
• W2015334764 hasAuthorship W2015334764A5005205857 @default.
• W2015334764 hasAuthorship W2015334764A5007745480 @default.
• W2015334764 hasAuthorship W2015334764A5032104300 @default.
• W2015334764 hasAuthorship W2015334764A5039796140 @default.
• W2015334764 hasAuthorship W2015334764A5044980958 @default.
• W2015334764 hasAuthorship W2015334764A5046236328 @default.
• W2015334764 hasConcept C126322002 @default.
• W2015334764 hasConcept C154317977 @default.
• W2015334764 hasConcept C181901479 @default.
• W2015334764 hasConcept C202751555 @default.
• W2015334764 hasConcept C203014093 @default.
• W2015334764 hasConcept C2776042228 @default.
• W2015334764 hasConcept C2776090121 @default.
• W2015334764 hasConcept C2777037409 @default.
• W2015334764 hasConcept C2777714996 @default.
• W2015334764 hasConcept C2777961210 @default.
• W2015334764 hasConcept C2778297628 @default.
• W2015334764 hasConcept C2778690821 @default.
• W2015334764 hasConcept C36333154 @default.
• W2015334764 hasConcept C39347974 @default.
• W2015334764 hasConcept C55493867 @default.
• W2015334764 hasConcept C71924100 @default.
• W2015334764 hasConcept C74172505 @default.
• W2015334764 hasConcept C86803240 @default.
• W2015334764 hasConcept C88675164 @default.
• W2015334764 hasConcept C8891405 @default.
• W2015334764 hasConceptScore W2015334764C126322002 @default.
• W2015334764 hasConceptScore W2015334764C154317977 @default.
• W2015334764 hasConceptScore W2015334764C181901479 @default.
• W2015334764 hasConceptScore W2015334764C202751555 @default.
• W2015334764 hasConceptScore W2015334764C203014093 @default.
• W2015334764 hasConceptScore W2015334764C2776042228 @default.
• W2015334764 hasConceptScore W2015334764C2776090121 @default.

• next