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• W2015335069 abstract "Infection of the pancreas has been a dreaded complication of acute pancreatitis for many years.33 Before the availability of computed tomography (CT), patients with severe pancreatitis were treated for at least 4 to 6 weeks before surgery was resorted to as a last life-saving effort in seriously ill, nearly moribund patients. In most of these patients, pancreatic necrosis involved infections, and the patient invariably required several relaparotomies for débridement of residual infected tissue. Mortality generally exceeded 50%. The situation has now changed with the availability of contrast-enhanced CT in most centers and ultrasound-guided or CT-guided aspiration of pancreatic necrosis for diagnosing pancreatic infection. Both procedures constitute the gold standards for detecting pancreatic necrosis and infection, thus enabling surgeons to perform pancreatic débridement at an earlier stage in patients with infected pancreatic necrosis or sterile necrosis with persistence of systemic toxicity.33 These detection methods raised the question of whether an antibiotic could or should be administered prophylactically to improve the clinical course and patient survival rate. The question has led to considerable controversy.5, 28, 45 Johnson29 reviewed experimental and clinical studies relating to antibiotic prophylaxis in acute pancreatitis. The authors critically review available data and review the approach to this frequent clinical debate." @default.
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• W2015335069 date "1999-09-01" @default.
• W2015335069 modified "2023-09-23" @default.
• W2015335069 title "THE ROLE OF ANTIBIOTIC PROPHYLAXIS IN THE TREATMENT OF ACUTE PANCREATITIS" @default.
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• W2015335069 doi "https://doi.org/10.1016/s0889-8553(05)70078-9" @default.
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