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• W2015335162 abstract "Background Systems level modeling of functional magnetic resonance imaging data has demonstrated dysfunction of several large-scale brain networks in schizophrenia. Anomalies across multiple functional networks associated with schizophrenia could be due to diffuse pathology across multiple networks or, alternatively, dysfunction at converging control(s) common to these networks. The right anterior insula has been shown to modulate activity in the central executive and default mode networks in healthy individuals. We tested the hypothesis that right anterior insula modulation of central executive and default mode networks is disrupted in schizophrenia and associated with cognitive deficits. Methods In 44 patients with schizophrenia and 44 healthy control subjects, we used seed-based resting state functional connectivity functional magnetic resonance imaging analysis to examine connectivity between right insular subregions and central executive/default mode network regions. We also performed two directed connectivity analyses of resting state data: Granger analysis and confirmatory structural equation modeling. Between-group differences in path coefficients were used to evaluate anterior insula modulation of central executive and default mode networks. Cognitive performance was assessed with the rapid visual information processing task, a test of sustained attention. Results With multiple connectivity techniques, we found compelling, corroborative evidence of disruption of right anterior insula modulation of central executive and default mode networks in patients with schizophrenia. The strength of right anterior insula modulation of these networks predicted cognitive performance. Conclusions Individuals with schizophrenia have impaired right anterior insula modulation of large-scale brain networks. The right anterior insula might be an emergent pathophysiological gateway in schizophrenia. Systems level modeling of functional magnetic resonance imaging data has demonstrated dysfunction of several large-scale brain networks in schizophrenia. Anomalies across multiple functional networks associated with schizophrenia could be due to diffuse pathology across multiple networks or, alternatively, dysfunction at converging control(s) common to these networks. The right anterior insula has been shown to modulate activity in the central executive and default mode networks in healthy individuals. We tested the hypothesis that right anterior insula modulation of central executive and default mode networks is disrupted in schizophrenia and associated with cognitive deficits. In 44 patients with schizophrenia and 44 healthy control subjects, we used seed-based resting state functional connectivity functional magnetic resonance imaging analysis to examine connectivity between right insular subregions and central executive/default mode network regions. We also performed two directed connectivity analyses of resting state data: Granger analysis and confirmatory structural equation modeling. Between-group differences in path coefficients were used to evaluate anterior insula modulation of central executive and default mode networks. Cognitive performance was assessed with the rapid visual information processing task, a test of sustained attention. With multiple connectivity techniques, we found compelling, corroborative evidence of disruption of right anterior insula modulation of central executive and default mode networks in patients with schizophrenia. The strength of right anterior insula modulation of these networks predicted cognitive performance. Individuals with schizophrenia have impaired right anterior insula modulation of large-scale brain networks. The right anterior insula might be an emergent pathophysiological gateway in schizophrenia." @default.
• W2015335162 created "2016-06-24" @default.
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• W2015335162 date "2013-09-01" @default.
• W2015335162 modified "2023-09-29" @default.
• W2015335162 title "Disruption of Anterior Insula Modulation of Large-Scale Brain Networks in Schizophrenia" @default.
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• W2015335162 cites W1968584171 @default.
• W2015335162 cites W1973254033 @default.
• W2015335162 cites W1990549981 @default.
• W2015335162 cites W1991771535 @default.
• W2015335162 cites W1993560189 @default.
• W2015335162 cites W2001366834 @default.
• W2015335162 cites W2004559917 @default.
• W2015335162 cites W2005933475 @default.
• W2015335162 cites W2008088150 @default.
• W2015335162 cites W2013583129 @default.
• W2015335162 cites W2014363173 @default.
• W2015335162 cites W2015867840 @default.
• W2015335162 cites W2016521818 @default.
• W2015335162 cites W2018963127 @default.
• W2015335162 cites W2020844317 @default.
• W2015335162 cites W2021768951 @default.
• W2015335162 cites W2022320465 @default.
• W2015335162 cites W2025832022 @default.
• W2015335162 cites W2034568201 @default.
• W2015335162 cites W2036751307 @default.
• W2015335162 cites W2041951497 @default.
• W2015335162 cites W2045844145 @default.
• W2015335162 cites W2047975465 @default.
• W2015335162 cites W2050463117 @default.
• W2015335162 cites W2054765060 @default.
• W2015335162 cites W2055345898 @default.
• W2015335162 cites W2071872757 @default.
• W2015335162 cites W2082630431 @default.
• W2015335162 cites W2093972428 @default.
• W2015335162 cites W2096029767 @default.
• W2015335162 cites W2098303658 @default.
• W2015335162 cites W2101194137 @default.
• W2015335162 cites W2101264293 @default.
• W2015335162 cites W2102139723 @default.
• W2015335162 cites W2103655132 @default.
• W2015335162 cites W2103717170 @default.
• W2015335162 cites W2107923981 @default.
• W2015335162 cites W2114638865 @default.
• W2015335162 cites W2115687188 @default.
• W2015335162 cites W2116658855 @default.
• W2015335162 cites W2118136004 @default.
• W2015335162 cites W2127070446 @default.
• W2015335162 cites W2129624700 @default.
• W2015335162 cites W2133144527 @default.
• W2015335162 cites W2133903921 @default.
• W2015335162 cites W2136435696 @default.
• W2015335162 cites W2138905229 @default.
• W2015335162 cites W2140582125 @default.
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• W2015335162 cites W2162593938 @default.
• W2015335162 cites W2163452374 @default.
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• W2015335162 doi "https://doi.org/10.1016/j.biopsych.2013.02.029" @default.
• W2015335162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3735654" @default.
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