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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015337210> ?p ?o ?g. }

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• W2015337210 abstract "Influenza A virus NS1 protein is a multifunctional virulence factor. Here, we report a crystal structure for the NS1 effector domain of avian influenza virus A/Duck/Albany/76. Comparison of this structure with that reported for a human strain shows both proteins share a common monomer conformation, albeit with subtle differences. Strikingly, our data reveal a novel helix–helix dimeric interface between monomers of the avian NS1 protein, which is also found in the human NS1 crystal lattice. We re-evaluate the current model of NS1 dimeric assembly, and provide biochemical evidence to show tryptophan-187 (a residue located at the helix–helix interface) is essential for dimerization of this effector domain." @default.
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• W2015337210 date "2008-08-01" @default.
• W2015337210 modified "2023-09-27" @default.
• W2015337210 title "Structure of an avian influenza A virus NS1 protein effector domain" @default.
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• W2015337210 doi "https://doi.org/10.1016/j.virol.2008.05.026" @default.
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