FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015338193> ?p ?o ?g. }

• W2015338193 abstract "Bacterial viruses were discovered in 1915 when Twort (49) observed a serially transmissible agent that destroys bacteria. Twort published this finding in a brief note that remained unnoticed until, two years later, d'Herelle (20) announced his, probably independent, discovery of an entirely analogous filtrable virus, to which he gave the name bacteriophage. D'Herelle's announcement caused an immediate sensation in the world of medical microbiology, because d'Herelle promulgated the idea that bacteriophages, rather than antibodies, are the chief agents of natural immunity against bacterial infections and should be most useful for a generalized therapy and prophylaxis. Despite holding to these, in the event quite mistaken, notions, d'Herelle managed to recognize bacterial viruses for what we know them to be today. Within two or three years of his original discovery he had invented the method of plaque counting that made possible the accurate titration of phage, and by 1923 he had outlined the true life cycle of the phage (21): the virus particle first attaches itself to the surface of the bacterium, then penetrates into the interior of the cell, where it reproduces itself to generate an issue of many progeny viruses. The progeny are liberated and ready to infect further bacteria when the infected cell finally bursts open, or undergoes lysis. Although, now in retrospect, these ideas not only seem eminently plausible but also happen to be true, they were accepted by few of d'Herelle's contemporaries. Especially the doctrine that the bacteriophage is a selfreproducing virus gave widespread offense, and such adversaries of d'Herelle as Bordet (3) and Gratia (19) preferred to think of it as a self-stimulating enzyme endogenous to the bacterium. Nevertheless, as Burnet (6) observed in 1934, however agnostic they have been in regard to the nature of a phage, all workers manipulated and in practice thought of it as an extrinsic, virus-like agent. Phage research made a Big Leap Forward with the appearance of M. Schlesinger on the scene. From about 1930 until his death in 1935, Schlesinger was the first to train the methods of molecular biology on bacterial viruses. Schlesinger showed by various indirect methods, such as the adsorption capacity of the bacterial cell for phage and the sedimentation velocity of the phage, that the virus particle has a maximum linear dimension of the order of 0.1 I& and a mass of about 4 x 10 -1eg." @default.
• W2015338193 created "2016-06-24" @default.
• W2015338193 creator A5066361932 @default.
• W2015338193 date "1962-03-01" @default.
• W2015338193 modified "2023-09-27" @default.
• W2015338193 title "A Short Epistemology of Bacteriophage Multiplication" @default.
• W2015338193 cites W138471655 @default.
• W2015338193 cites W1474217982 @default.
• W2015338193 cites W1534071126 @default.
• W2015338193 cites W1891473777 @default.
• W2015338193 cites W1901048910 @default.
• W2015338193 cites W1971422589 @default.
• W2015338193 cites W1987797501 @default.
• W2015338193 cites W1988037647 @default.
• W2015338193 cites W1989948695 @default.
• W2015338193 cites W2008440482 @default.
• W2015338193 cites W2026651391 @default.
• W2015338193 cites W2028296407 @default.
• W2015338193 cites W2032619610 @default.
• W2015338193 cites W2046638965 @default.
• W2015338193 cites W2069100555 @default.
• W2015338193 cites W2082945679 @default.
• W2015338193 cites W2127674396 @default.
• W2015338193 cites W2131535785 @default.
• W2015338193 cites W2135655144 @default.
• W2015338193 cites W2153834532 @default.
• W2015338193 cites W2217782399 @default.
• W2015338193 cites W2255656164 @default.
• W2015338193 cites W2403241400 @default.
• W2015338193 doi "https://doi.org/10.1016/s0006-3495(62)86946-x" @default.
• W2015338193 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1366474" @default.
• W2015338193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14039501" @default.
• W2015338193 hasPublicationYear "1962" @default.
• W2015338193 type Work @default.
• W2015338193 sameAs 2015338193 @default.
• W2015338193 citedByCount "1" @default.
• W2015338193 countsByYear W20153381932019 @default.
• W2015338193 crossrefType "journal-article" @default.
• W2015338193 hasAuthorship W2015338193A5066361932 @default.
• W2015338193 hasBestOaLocation W20153381931 @default.
• W2015338193 hasConcept C104317684 @default.
• W2015338193 hasConcept C121332964 @default.
• W2015338193 hasConcept C138885662 @default.
• W2015338193 hasConcept C159047783 @default.
• W2015338193 hasConcept C166957645 @default.
• W2015338193 hasConcept C203014093 @default.
• W2015338193 hasConcept C2522874641 @default.
• W2015338193 hasConcept C27206212 @default.
• W2015338193 hasConcept C2776211767 @default.
• W2015338193 hasConcept C2776441376 @default.
• W2015338193 hasConcept C2778059882 @default.
• W2015338193 hasConcept C2779662365 @default.
• W2015338193 hasConcept C2910978944 @default.
• W2015338193 hasConcept C523546767 @default.
• W2015338193 hasConcept C54355233 @default.
• W2015338193 hasConcept C547475151 @default.
• W2015338193 hasConcept C57409179 @default.
• W2015338193 hasConcept C62520636 @default.
• W2015338193 hasConcept C86803240 @default.
• W2015338193 hasConcept C89423630 @default.
• W2015338193 hasConcept C95457728 @default.
• W2015338193 hasConceptScore W2015338193C104317684 @default.
• W2015338193 hasConceptScore W2015338193C121332964 @default.
• W2015338193 hasConceptScore W2015338193C138885662 @default.
• W2015338193 hasConceptScore W2015338193C159047783 @default.
• W2015338193 hasConceptScore W2015338193C166957645 @default.
• W2015338193 hasConceptScore W2015338193C203014093 @default.
• W2015338193 hasConceptScore W2015338193C2522874641 @default.
• W2015338193 hasConceptScore W2015338193C27206212 @default.
• W2015338193 hasConceptScore W2015338193C2776211767 @default.
• W2015338193 hasConceptScore W2015338193C2776441376 @default.
• W2015338193 hasConceptScore W2015338193C2778059882 @default.
• W2015338193 hasConceptScore W2015338193C2779662365 @default.
• W2015338193 hasConceptScore W2015338193C2910978944 @default.
• W2015338193 hasConceptScore W2015338193C523546767 @default.
• W2015338193 hasConceptScore W2015338193C54355233 @default.
• W2015338193 hasConceptScore W2015338193C547475151 @default.
• W2015338193 hasConceptScore W2015338193C57409179 @default.
• W2015338193 hasConceptScore W2015338193C62520636 @default.
• W2015338193 hasConceptScore W2015338193C86803240 @default.
• W2015338193 hasConceptScore W2015338193C89423630 @default.
• W2015338193 hasConceptScore W2015338193C95457728 @default.
• W2015338193 hasLocation W20153381931 @default.
• W2015338193 hasLocation W20153381932 @default.
• W2015338193 hasLocation W20153381933 @default.
• W2015338193 hasOpenAccess W2015338193 @default.
• W2015338193 hasPrimaryLocation W20153381931 @default.
• W2015338193 hasRelatedWork W154782128 @default.
• W2015338193 hasRelatedWork W188646393 @default.
• W2015338193 hasRelatedWork W1976665978 @default.
• W2015338193 hasRelatedWork W2013154460 @default.
• W2015338193 hasRelatedWork W2107229050 @default.
• W2015338193 hasRelatedWork W2141579132 @default.
• W2015338193 hasRelatedWork W2347453665 @default.
• W2015338193 hasRelatedWork W2463962182 @default.
• W2015338193 hasRelatedWork W2480815922 @default.
• W2015338193 hasRelatedWork W2735981929 @default.
• W2015338193 hasRelatedWork W85168750 @default.
• W2015338193 isParatext "false" @default.
• W2015338193 isRetracted "false" @default.

• next