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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015338946> ?p ?o ?g. }

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• W2015338946 abstract "Pin1 actively regulates diverse biological/pathological processes, but little is known about the regulatory mechanisms of its cellular localization. In this study, we report that the endogenous Pin1 is distributed in both nucleus and cytoplasm. We found that point mutations of several basic amino acids in the PPIase domain of Pin1 significantly compromise its nuclear localization. Such inhibition is independent of Pin1 enzymatic activity, and is mainly due to the defects in the nuclear import. A novel sequence harboring these residues was identified as a putative nuclear localization signal (NLS) of Pin1. Importin alpha5 of the nuclear import machinery was found to interact with Pin1." @default.
• W2015338946 created "2016-06-24" @default.
• W2015338946 creator A5044596435 @default.
• W2015338946 creator A5053638116 @default.
• W2015338946 date "2008-12-11" @default.
• W2015338946 modified "2023-10-16" @default.
• W2015338946 title "Nuclear import of Pin1 is mediated by a novel sequence in the PPIase domain" @default.
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• W2015338946 doi "https://doi.org/10.1016/j.febslet.2008.12.011" @default.
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