FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015339598> ?p ?o ?g. }

• W2015339598 endingPage "649" @default.
• W2015339598 startingPage "640" @default.
• W2015339598 abstract "Abstract The aim of this study was to compare the efficacy of high‐dose interferon (IFN)‐α‐2b with standard dose of IFN‐α‐2b in combination with ribavirin (RBV) for patients with chronic hepatitis C virus (HCV) infection, and to investigate the predictive factors associated with virological response. Two hundred Japanese patients with high HCV viral load (>100 KIU/ml) were randomized to 6 or 10 mega units (MU) of 24‐week IFN‐α‐2b with RBV. Predictive factors were investigated; including pretreatment amino acid (aa) sequences of the core region and the IFN‐sensitive determining region (ISDR). The sustained virological response rate was not different in the two groups (24% vs. 30%) but the incidence of depression was significantly higher in the 10 MU group than 6 MU group (7% vs. 0%, P = 0.02). Younger age (<60) and HCV genotype (2a/b) were significant predictors of sustained virological response. In patients infected with genotype 1b, substitutions of core aa 70 and/or 91 were predictive for non‐virological response ( P < 0.001), and substitutions in the ISDR was observed frequently in virological responders. Early viral kinetics study showed that serum HCV core antigen decreased more slowly in both patients with aa 70 and/or 91 substitutions in the core and with absence of substitutions in the ISDR. In conclusion, the use of a higher dose of IFN‐α‐2b in combination with RBV did not improve virological response but resulted in higher incidence of depression. Amino acid substitutions in the core and ISDR are predictive of virological response to the therapy in patients with genotype 1b and high viral load. J. Med. Virol. 81:640–649, 2009 © 2009 Wiley‐Liss, Inc." @default.
• W2015339598 created "2016-06-24" @default.
• W2015339598 creator A5019195799 @default.
• W2015339598 creator A5019763674 @default.
• W2015339598 creator A5022484621 @default.
• W2015339598 creator A5023958825 @default.
• W2015339598 creator A5027196488 @default.
• W2015339598 creator A5031469873 @default.
• W2015339598 creator A5034077858 @default.
• W2015339598 creator A5048673628 @default.
• W2015339598 creator A5051242188 @default.
• W2015339598 date "2009-02-23" @default.
• W2015339598 modified "2023-10-16" @default.
• W2015339598 title "Randomized trial of high-dose interferon-α-2b combined with ribavirin in patients with chronic hepatitis C: Correlation between amino acid substitutions in the core/NS5A region and virological response to interferon therapy" @default.
• W2015339598 cites W1964494489 @default.
• W2015339598 cites W1968426124 @default.
• W2015339598 cites W1971792395 @default.
• W2015339598 cites W1978883570 @default.
• W2015339598 cites W1979065789 @default.
• W2015339598 cites W1982433898 @default.
• W2015339598 cites W1985588212 @default.
• W2015339598 cites W1992109850 @default.
• W2015339598 cites W1992239172 @default.
• W2015339598 cites W1995565071 @default.
• W2015339598 cites W1999494993 @default.
• W2015339598 cites W2010855805 @default.
• W2015339598 cites W2016205218 @default.
• W2015339598 cites W2024049300 @default.
• W2015339598 cites W2027545702 @default.
• W2015339598 cites W2033929071 @default.
• W2015339598 cites W2046714103 @default.
• W2015339598 cites W2046858735 @default.
• W2015339598 cites W2059457521 @default.
• W2015339598 cites W2066892848 @default.
• W2015339598 cites W2071586067 @default.
• W2015339598 cites W2075293916 @default.
• W2015339598 cites W2075660007 @default.
• W2015339598 cites W2079059990 @default.
• W2015339598 cites W2084742492 @default.
• W2015339598 cites W2088053309 @default.
• W2015339598 cites W2096959824 @default.
• W2015339598 cites W2105599476 @default.
• W2015339598 cites W2107639148 @default.
• W2015339598 cites W2108639262 @default.
• W2015339598 cites W2112360308 @default.
• W2015339598 cites W2121242678 @default.
• W2015339598 cites W2122153421 @default.
• W2015339598 cites W2122494591 @default.
• W2015339598 cites W2127685726 @default.
• W2015339598 cites W2133964987 @default.
• W2015339598 cites W2141228361 @default.
• W2015339598 cites W2145355617 @default.
• W2015339598 cites W2150640672 @default.
• W2015339598 cites W2150757291 @default.
• W2015339598 cites W2158694627 @default.
• W2015339598 cites W2159954692 @default.
• W2015339598 cites W2166971952 @default.
• W2015339598 cites W2169391152 @default.
• W2015339598 cites W2317554121 @default.
• W2015339598 cites W2335845212 @default.
• W2015339598 doi "https://doi.org/10.1002/jmv.21438" @default.
• W2015339598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19235866" @default.
• W2015339598 hasPublicationYear "2009" @default.
• W2015339598 type Work @default.
• W2015339598 sameAs 2015339598 @default.
• W2015339598 citedByCount "28" @default.
• W2015339598 countsByYear W20153395982012 @default.
• W2015339598 countsByYear W20153395982013 @default.
• W2015339598 countsByYear W20153395982014 @default.
• W2015339598 countsByYear W20153395982015 @default.
• W2015339598 countsByYear W20153395982017 @default.
• W2015339598 crossrefType "journal-article" @default.
• W2015339598 hasAuthorship W2015339598A5019195799 @default.
• W2015339598 hasAuthorship W2015339598A5019763674 @default.
• W2015339598 hasAuthorship W2015339598A5022484621 @default.
• W2015339598 hasAuthorship W2015339598A5023958825 @default.
• W2015339598 hasAuthorship W2015339598A5027196488 @default.
• W2015339598 hasAuthorship W2015339598A5031469873 @default.
• W2015339598 hasAuthorship W2015339598A5034077858 @default.
• W2015339598 hasAuthorship W2015339598A5048673628 @default.
• W2015339598 hasAuthorship W2015339598A5051242188 @default.
• W2015339598 hasConcept C126322002 @default.
• W2015339598 hasConcept C142462285 @default.
• W2015339598 hasConcept C159047783 @default.
• W2015339598 hasConcept C2522874641 @default.
• W2015339598 hasConcept C2776178377 @default.
• W2015339598 hasConcept C2776408679 @default.
• W2015339598 hasConcept C2776455275 @default.
• W2015339598 hasConcept C2777103181 @default.
• W2015339598 hasConcept C2780040827 @default.
• W2015339598 hasConcept C2781463415 @default.
• W2015339598 hasConcept C71924100 @default.
• W2015339598 hasConcept C90924648 @default.
• W2015339598 hasConceptScore W2015339598C126322002 @default.
• W2015339598 hasConceptScore W2015339598C142462285 @default.
• W2015339598 hasConceptScore W2015339598C159047783 @default.
• W2015339598 hasConceptScore W2015339598C2522874641 @default.
• W2015339598 hasConceptScore W2015339598C2776178377 @default.

• next