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• W2015339924 abstract "The intronic Ig heavy chain (IgH) enhancer, which consists of the core enhancer flanked by 5′ and 3′ matrix attachment regions, has been implicated in control of IgH locus recombination and transcription. To elucidate the regulatory functions of the core enhancer and its associated matrix attachment regions in the endogenous IgH locus, we have introduced targeted deletions of these elements, both individually and in combination, into an IgH a/b -heterozygous embryonic stem cell line. These embryonic stem cells were used to generate chimeric mice by recombination activating gene-2 (Rag-2)-deficient blastocyst complementation, and the effects of the introduced mutations were assayed in mutant B cells. We find that the core enhancer is necessary and sufficient to promote normal variable (V), diversity (D), and joining (J) segment recombination in developing B lineage cells and IgH locus transcription in mature B cells. Surprisingly, the 5′ and 3′ matrix attachment regions were dispensable for these processes." @default.
• W2015339924 created "2016-06-24" @default.
• W2015339924 creator A5000388529 @default.
• W2015339924 creator A5023019028 @default.
• W2015339924 creator A5033821931 @default.
• W2015339924 creator A5070465724 @default.
• W2015339924 creator A5080477832 @default.
• W2015339924 date "1999-02-16" @default.
• W2015339924 modified "2023-09-26" @default.
• W2015339924 title "Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions" @default.
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• W2015339924 doi "https://doi.org/10.1073/pnas.96.4.1526" @default.
• W2015339924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/15504" @default.
• W2015339924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9990057" @default.
• W2015339924 hasPublicationYear "1999" @default.
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