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- W2015341735 abstract "Recently, voltage-induced transport of dsDNA molecules through nano pores in graphene membranes has been demonstrated experimentally. Graphene, due to its sub-nanometer thickness, shows great potential to realize DNA sequencing at single-base resolution. The kinetics of electrophoretically driven DNA translocation through graphene nanopores was studied using molecular dynamics simulations (Sathe et al., ACS Nano, in press). The simulations provide guidance in the design of graphene-based DNA sequencing devices and single molecule sensors. We report the effects of applied voltage, DNA conformation, pore charge as well as sequence on the translocation characteristics of DNA revealed in the simulations. Simulations yield also, consistent with recent measurements, the characteristics of ion currents passing pores alongside with DNA. The simulations demonstrate, furthermore, that under suitable voltage bias conditions A-T and G-C base pairs can be discriminated using graphene nanopores." @default.
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- W2015341735 date "2012-01-01" @default.
- W2015341735 modified "2023-10-14" @default.
- W2015341735 title "Computational Investigation of Graphene Nano Pore DNA Detection" @default.
- W2015341735 doi "https://doi.org/10.1016/j.bpj.2011.11.1114" @default.
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