Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015341778> ?p ?o ?g. }
- W2015341778 endingPage "355" @default.
- W2015341778 startingPage "340" @default.
- W2015341778 abstract "An organ unique to mammals, the mammary gland develops 90% of its mass after birth and experiences the pregnancylactation-involution cycle (PL cycle) during reproduction. To understand mammogenesis at the transcriptomic level and using a ribo-minus RNA-seq protocol, we acquired greater than 50 million reads each for the mouse mammary gland during pregnancy (day 12 of pregnancy), lactation (day 14 of lactation), and involution (day 7 of involution). The pregnancy-, lactation- and involution-related sequencing reads were assembled into 17344, 10160, and 13739 protein-coding transcripts and 1803, 828, and 1288 non-coding RNAs (ncRNAs), respectively. Differentially expressed genes (DEGs) were defined in the three samples, which comprised 4843 DEGs (749 up-regulated and 4094 down-regulated) from pregnancy to lactation and 4926 DEGs (4706 up-regulated and 220 down-regulated) from lactation to involution. Besides the obvious and substantive up- and down-regulation of the DEGs, we observe that lysosomal enzymes were highly expressed and that their expression coincided with milk secretion. Further analysis of transcription factors such as Trps1, Gtf2i, Tcf7l2, Nupr1, Vdr, Rb1, and Aebp1, and ncRNAs such as mir-125b, Let7, mir-146a, and mir-15 has enabled us to identify key regulators in mammary gland development and the PL cycle." @default.
- W2015341778 created "2016-06-24" @default.
- W2015341778 creator A5000255298 @default.
- W2015341778 creator A5007463264 @default.
- W2015341778 creator A5008469361 @default.
- W2015341778 creator A5009289581 @default.
- W2015341778 creator A5010607811 @default.
- W2015341778 creator A5032131547 @default.
- W2015341778 creator A5042506228 @default.
- W2015341778 creator A5051056007 @default.
- W2015341778 creator A5087713759 @default.
- W2015341778 creator A5088031037 @default.
- W2015341778 date "2014-02-19" @default.
- W2015341778 modified "2023-10-12" @default.
- W2015341778 title "Transcriptomic analysis reveals key regulators of mammogenesis and the pregnancy-lactation cycle" @default.
- W2015341778 cites W112945881 @default.
- W2015341778 cites W150518419 @default.
- W2015341778 cites W1512981737 @default.
- W2015341778 cites W1518023284 @default.
- W2015341778 cites W1601214065 @default.
- W2015341778 cites W174960154 @default.
- W2015341778 cites W1777054565 @default.
- W2015341778 cites W1854096392 @default.
- W2015341778 cites W1881270362 @default.
- W2015341778 cites W1945678278 @default.
- W2015341778 cites W1967798906 @default.
- W2015341778 cites W1974744572 @default.
- W2015341778 cites W1977808594 @default.
- W2015341778 cites W1978395942 @default.
- W2015341778 cites W1979122274 @default.
- W2015341778 cites W1980025879 @default.
- W2015341778 cites W1981509058 @default.
- W2015341778 cites W1982210596 @default.
- W2015341778 cites W1985373496 @default.
- W2015341778 cites W1985563073 @default.
- W2015341778 cites W1986395175 @default.
- W2015341778 cites W1989077543 @default.
- W2015341778 cites W1989155338 @default.
- W2015341778 cites W1991437477 @default.
- W2015341778 cites W1997416811 @default.
- W2015341778 cites W1997694367 @default.
- W2015341778 cites W2001708910 @default.
- W2015341778 cites W2003877633 @default.
- W2015341778 cites W2004171992 @default.
- W2015341778 cites W2004419591 @default.
- W2015341778 cites W2013762364 @default.
- W2015341778 cites W2018598495 @default.
- W2015341778 cites W2019171053 @default.
- W2015341778 cites W2019249398 @default.
- W2015341778 cites W2019307755 @default.
- W2015341778 cites W2021239799 @default.
- W2015341778 cites W2021469012 @default.
- W2015341778 cites W2022513471 @default.
- W2015341778 cites W2029526923 @default.
- W2015341778 cites W2029529001 @default.
- W2015341778 cites W2030288656 @default.
- W2015341778 cites W2033963683 @default.
- W2015341778 cites W2035297183 @default.
- W2015341778 cites W2035360185 @default.
- W2015341778 cites W2039057191 @default.
- W2015341778 cites W2043586699 @default.
- W2015341778 cites W2045336724 @default.
- W2015341778 cites W2050345315 @default.
- W2015341778 cites W2052677441 @default.
- W2015341778 cites W2052949054 @default.
- W2015341778 cites W2053854235 @default.
- W2015341778 cites W2057400274 @default.
- W2015341778 cites W2059998775 @default.
- W2015341778 cites W2065427389 @default.
- W2015341778 cites W2073749890 @default.
- W2015341778 cites W2074733595 @default.
- W2015341778 cites W2075363849 @default.
- W2015341778 cites W2076517134 @default.
- W2015341778 cites W2089902916 @default.
- W2015341778 cites W2093643588 @default.
- W2015341778 cites W2094166501 @default.
- W2015341778 cites W2094538472 @default.
- W2015341778 cites W2096637314 @default.
- W2015341778 cites W2097191932 @default.
- W2015341778 cites W2097695611 @default.
- W2015341778 cites W2099159895 @default.
- W2015341778 cites W2100739686 @default.
- W2015341778 cites W2111556368 @default.
- W2015341778 cites W2114872517 @default.
- W2015341778 cites W2117788306 @default.
- W2015341778 cites W2120681057 @default.
- W2015341778 cites W2120735622 @default.
- W2015341778 cites W2120994878 @default.
- W2015341778 cites W2129802808 @default.
- W2015341778 cites W2131219323 @default.
- W2015341778 cites W2132194692 @default.
- W2015341778 cites W2135836598 @default.
- W2015341778 cites W2135857763 @default.
- W2015341778 cites W2138123091 @default.
- W2015341778 cites W2142626890 @default.
- W2015341778 cites W2146224901 @default.
- W2015341778 cites W2147028876 @default.
- W2015341778 cites W2148772545 @default.