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• W2015341886 abstract "Regenerating adult central nervous system (CNS) neurons must re-establish synaptic circuits in an environment very different from that present during development. However, the complexity of CNS circuitry has made it extremely difficult to assess the selectivity and mechanisms of synaptic regeneration at the cellular level in vivo. The synaptic preferences of adult photoreceptors were examined by using a defined cell culture system known to support regenerative process growth, presynaptic varicosity formation, and establishment of functional synapses. Immunolabeling for synaptic vesicle protein 2 and ultrastructural analysis demonstrated that cell-cell contacts made by photoreceptors were synaptic in nature. Target selectivity was determined by quantitative analysis of contacts onto normal and novel target cell types in cultures in which opportunities to contact all retinal cell types were present. Target cells were identified by morphology and immunolabeling for the amino acid neurotransmitters glutamate, aspartate, gamma-aminobutyric acid (GABA), and glycine. Regenerating photoreceptors showed a strong preference for novel multipolar cell targets (amacrine and ganglion cells) over normal photoreceptor, horizontal, and bipolar cell targets. Additionally, photoreceptors were selective for targets containing the transmitter GABA. These results indicate first, that the normal synaptic partners for photoreceptors are not intrinsically the optimal targets for regenerative synapse formation, and second, that GABA may modulate synaptic targeting by adult photoreceptors." @default.
• W2015341886 created "2016-06-24" @default.
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• W2015341886 date "1996-12-16" @default.
• W2015341886 modified "2023-10-12" @default.
• W2015341886 title "Morphologic and neurochemical target selectivity of regenerating adult photoreceptors in vitro" @default.
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• W2015341886 cites W1889253785 @default.
• W2015341886 cites W1897234079 @default.
• W2015341886 cites W1907902983 @default.
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• W2015341886 doi "https://doi.org/10.1002/(sici)1096-9861(19961216)376:3<476::aid-cne9>3.0.co;2-#" @default.
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