FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015346124> ?p ?o ?g. }

• W2015346124 endingPage "578" @default.
• W2015346124 startingPage "569" @default.
• W2015346124 abstract "In mammalian cells and yeasts, amino acid motifs in the cytoplasmic tails of transmembrane proteins play a prominent role in protein targeting in the early secretory pathway by mediating localization to or rapid export from the endoplasmic reticulum (ER). However, early sorting events are poorly characterized in protozoan parasites. Here, we show that a C-terminal QKTT sequence mediates the ER localization of chimeric reporter constructs consisting of bacterial alkaline phosphatase (BAP) fused to the transmembrane domain (TMD) and truncated cytoplasmic tail of the human low-density lipoprotein receptor (LDL) receptor or of murine lysosome-associated membrane protein (lamp-1) in Toxoplasma gondii. The cytoplasmic tail of human TGN46 also determines ER localization of BAP chimeras in the parasite, but this can be overcome by the addition at the C-terminus of the tail of an acidic patch, which functions as an ER export signal in conjunction with an upstream tyrosine motif. These results suggest that COPI-dependent ER retrieval and COPII-dependent export mechanisms mediated by KKXX and DXE motifs of mammalian cells are generally conserved in T. gondii. In contrast, the failure of the QKTT motif and TGN46 cytoplasmic tail to induce steady-state ER localization of vesicular stomatitis virus glycoprotein (VSVG) chimeras in HeLa and NRK cells indicates that significant differences in early secretory trafficking also exist." @default.
• W2015346124 created "2016-06-24" @default.
• W2015346124 creator A5027225478 @default.
• W2015346124 creator A5082148123 @default.
• W2015346124 date "2000-12-01" @default.
• W2015346124 modified "2023-09-30" @default.
• W2015346124 title "Cytoplasmic tail motifs mediate endoplasmic reticulum localization and export of transmembrane reporters in the protozoan parasite Toxoplasma gondii" @default.
• W2015346124 cites W1275105234 @default.
• W2015346124 cites W141200506 @default.
• W2015346124 cites W1481682126 @default.
• W2015346124 cites W1524907729 @default.
• W2015346124 cites W1537657586 @default.
• W2015346124 cites W170304149 @default.
• W2015346124 cites W1965260691 @default.
• W2015346124 cites W1966398753 @default.
• W2015346124 cites W1968774879 @default.
• W2015346124 cites W1968784370 @default.
• W2015346124 cites W1978689611 @default.
• W2015346124 cites W2003519864 @default.
• W2015346124 cites W2010728293 @default.
• W2015346124 cites W2012040490 @default.
• W2015346124 cites W2012375411 @default.
• W2015346124 cites W2017284486 @default.
• W2015346124 cites W2017902030 @default.
• W2015346124 cites W2048715836 @default.
• W2015346124 cites W2054459441 @default.
• W2015346124 cites W2054593368 @default.
• W2015346124 cites W2054771034 @default.
• W2015346124 cites W2073695321 @default.
• W2015346124 cites W2078823297 @default.
• W2015346124 cites W2082103548 @default.
• W2015346124 cites W2082861222 @default.
• W2015346124 cites W2089764554 @default.
• W2015346124 cites W2092356580 @default.
• W2015346124 cites W2094913735 @default.
• W2015346124 cites W2107312415 @default.
• W2015346124 cites W2120598289 @default.
• W2015346124 cites W2121624499 @default.
• W2015346124 cites W2132985208 @default.
• W2015346124 cites W2142329004 @default.
• W2015346124 cites W2142538346 @default.
• W2015346124 cites W2167988140 @default.
• W2015346124 cites W2171743890 @default.
• W2015346124 cites W2400954299 @default.
• W2015346124 cites W2408822320 @default.
• W2015346124 cites W86630917 @default.
• W2015346124 doi "https://doi.org/10.1046/j.1462-5822.2000.00081.x" @default.
• W2015346124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11207609" @default.
• W2015346124 hasPublicationYear "2000" @default.
• W2015346124 type Work @default.
• W2015346124 sameAs 2015346124 @default.
• W2015346124 citedByCount "20" @default.
• W2015346124 countsByYear W20153461242013 @default.
• W2015346124 countsByYear W20153461242014 @default.
• W2015346124 countsByYear W20153461242020 @default.
• W2015346124 crossrefType "journal-article" @default.
• W2015346124 hasAuthorship W2015346124A5027225478 @default.
• W2015346124 hasAuthorship W2015346124A5082148123 @default.
• W2015346124 hasBestOaLocation W20153461241 @default.
• W2015346124 hasConcept C104317684 @default.
• W2015346124 hasConcept C113584667 @default.
• W2015346124 hasConcept C118892022 @default.
• W2015346124 hasConcept C119062480 @default.
• W2015346124 hasConcept C143065580 @default.
• W2015346124 hasConcept C144647389 @default.
• W2015346124 hasConcept C156399914 @default.
• W2015346124 hasConcept C158617107 @default.
• W2015346124 hasConcept C159654299 @default.
• W2015346124 hasConcept C162740809 @default.
• W2015346124 hasConcept C170493617 @default.
• W2015346124 hasConcept C190062978 @default.
• W2015346124 hasConcept C199229279 @default.
• W2015346124 hasConcept C24530287 @default.
• W2015346124 hasConcept C2778043179 @default.
• W2015346124 hasConcept C2778128430 @default.
• W2015346124 hasConcept C41625074 @default.
• W2015346124 hasConcept C49039625 @default.
• W2015346124 hasConcept C54355233 @default.
• W2015346124 hasConcept C55493867 @default.
• W2015346124 hasConcept C559089031 @default.
• W2015346124 hasConcept C57581600 @default.
• W2015346124 hasConcept C6492254 @default.
• W2015346124 hasConcept C86803240 @default.
• W2015346124 hasConcept C95444343 @default.
• W2015346124 hasConceptScore W2015346124C104317684 @default.
• W2015346124 hasConceptScore W2015346124C113584667 @default.
• W2015346124 hasConceptScore W2015346124C118892022 @default.
• W2015346124 hasConceptScore W2015346124C119062480 @default.
• W2015346124 hasConceptScore W2015346124C143065580 @default.
• W2015346124 hasConceptScore W2015346124C144647389 @default.
• W2015346124 hasConceptScore W2015346124C156399914 @default.
• W2015346124 hasConceptScore W2015346124C158617107 @default.
• W2015346124 hasConceptScore W2015346124C159654299 @default.
• W2015346124 hasConceptScore W2015346124C162740809 @default.
• W2015346124 hasConceptScore W2015346124C170493617 @default.
• W2015346124 hasConceptScore W2015346124C190062978 @default.
• W2015346124 hasConceptScore W2015346124C199229279 @default.
• W2015346124 hasConceptScore W2015346124C24530287 @default.

• next