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- W2015346163 abstract "Pluronic block copolymers have been used extensively in a variety of pharmaceutical formulations including delivery of low molecular mass drugs and polypeptides. This review describes novel applications of Pluronic block copolymers in the treatment of drug-resistant tumors. It has been discovered that Pluronic block copolymers interact with multidrug-resistant cancer (MDR) tumors resulting in drastic sensitization of these tumors with respect to various anticancer agents, particularly, anthracycline antibiotics. Furthermore, Pluronic affects several distinct drug resistance mechanisms including inhibition of drug efflux transporters, abolishing drug sequestration in acidic vesicles as well as inhibiting the glutathione/glutathione S-transferase detoxification system. All these mechanisms of drug resistance are energy-dependent and therefore ATP depletion induced by Pluronic block copolymers in MDR cells is considered as one potential reason for chemosensitization of these cells. Following validation using in vitro and in vivo models, a formulation containing doxorubicin and Pluronic mixture (L61 and F127), SP1049C, has been evaluated in phase I clinical trials. Further mechanistic studies and clinical evaluations of these systems are in progress." @default.
- W2015346163 created "2016-06-24" @default.
- W2015346163 creator A5006955096 @default.
- W2015346163 creator A5060362637 @default.
- W2015346163 creator A5088018714 @default.
- W2015346163 date "2002-09-01" @default.
- W2015346163 modified "2023-10-17" @default.
- W2015346163 title "Pluronic® block copolymers for overcoming drug resistance in cancer" @default.
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- W2015346163 cites W1271999003 @default.
- W2015346163 cites W132061808 @default.
- W2015346163 cites W1490816031 @default.
- W2015346163 cites W1531237743 @default.
- W2015346163 cites W1565544493 @default.
- W2015346163 cites W1608143264 @default.
- W2015346163 cites W1724778664 @default.
- W2015346163 cites W182509504 @default.
- W2015346163 cites W1917639811 @default.
- W2015346163 cites W1935024855 @default.
- W2015346163 cites W1947290715 @default.
- W2015346163 cites W1962589009 @default.
- W2015346163 cites W1963483494 @default.
- W2015346163 cites W1963500271 @default.
- W2015346163 cites W1965129145 @default.
- W2015346163 cites W1967129717 @default.
- W2015346163 cites W1967470768 @default.
- W2015346163 cites W1969125730 @default.
- W2015346163 cites W1973641448 @default.
- W2015346163 cites W1985461684 @default.
- W2015346163 cites W1988234658 @default.
- W2015346163 cites W1989517413 @default.
- W2015346163 cites W1989886196 @default.
- W2015346163 cites W1990206463 @default.
- W2015346163 cites W1993895985 @default.
- W2015346163 cites W1994201724 @default.
- W2015346163 cites W1995713671 @default.
- W2015346163 cites W1999770972 @default.
- W2015346163 cites W2009188082 @default.
- W2015346163 cites W2011396160 @default.
- W2015346163 cites W2012841076 @default.
- W2015346163 cites W2013127185 @default.
- W2015346163 cites W2013995823 @default.
- W2015346163 cites W2014051119 @default.
- W2015346163 cites W2016880770 @default.
- W2015346163 cites W201774895 @default.
- W2015346163 cites W2020631100 @default.
- W2015346163 cites W2025066311 @default.
- W2015346163 cites W2026744592 @default.
- W2015346163 cites W2030863859 @default.
- W2015346163 cites W2031206690 @default.
- W2015346163 cites W2031728380 @default.
- W2015346163 cites W2037302753 @default.
- W2015346163 cites W2042677337 @default.
- W2015346163 cites W2044050922 @default.
- W2015346163 cites W2044468753 @default.
- W2015346163 cites W2044556787 @default.
- W2015346163 cites W2044566946 @default.
- W2015346163 cites W2046188261 @default.
- W2015346163 cites W2046750894 @default.
- W2015346163 cites W2048268258 @default.
- W2015346163 cites W2049462859 @default.
- W2015346163 cites W2052366563 @default.
- W2015346163 cites W2054609339 @default.
- W2015346163 cites W2058394127 @default.
- W2015346163 cites W2059294902 @default.
- W2015346163 cites W2060517401 @default.
- W2015346163 cites W2061106944 @default.
- W2015346163 cites W2061960914 @default.
- W2015346163 cites W2071610288 @default.
- W2015346163 cites W2078317923 @default.
- W2015346163 cites W2079566440 @default.
- W2015346163 cites W2081215618 @default.
- W2015346163 cites W2084587351 @default.
- W2015346163 cites W2085504000 @default.
- W2015346163 cites W2087145317 @default.
- W2015346163 cites W2089165482 @default.
- W2015346163 cites W2096535122 @default.
- W2015346163 cites W2098142549 @default.
- W2015346163 cites W2102424404 @default.
- W2015346163 cites W2105934299 @default.
- W2015346163 cites W2110475952 @default.
- W2015346163 cites W2117771496 @default.
- W2015346163 cites W2117826610 @default.
- W2015346163 cites W2137680793 @default.
- W2015346163 cites W2155199761 @default.
- W2015346163 cites W2171614785 @default.
- W2015346163 cites W2189485037 @default.
- W2015346163 cites W2404355448 @default.
- W2015346163 cites W2414186991 @default.
- W2015346163 cites W253334427 @default.
- W2015346163 cites W258442487 @default.
- W2015346163 cites W4251751811 @default.
- W2015346163 doi "https://doi.org/10.1016/s0169-409x(02)00047-9" @default.
- W2015346163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12204601" @default.
- W2015346163 hasPublicationYear "2002" @default.
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