FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015347798> ?p ?o ?g. }

• W2015347798 endingPage "155" @default.
• W2015347798 startingPage "146" @default.
• W2015347798 abstract "Previously we showed that the organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate (p-XSC)1 inhibits 4-nitroquinoline-N-oxide (4-NQO)-induced tongue tumorigenesis in Fisher rats. Here we investigate possible mechanisms of this inhibition by monitoring mutagenesis and p53 protein levels in lacI and conventional Fisher rats treated with: (1) a carcinogenic dose of 4-NQO for 10 weeks in drinking water, (2) 4-NQO + p-XSC (15 ppm as selenium), and (3) 4-NQO followed by p-XSC. For mutagenesis studies, rats were euthanized at 7, 12 or 23 weeks after the start of 4-NQO. For studies on p53 levels, rats were euthanized at 11, 15 and 23 weeks. Appropriate controls were also monitored. In the 4-NQO-alone groups, the mutant fraction (MF) in the cII gene in tongue increased at least 50× background level. The MF (in units of mutants/105 plaque forming units) for the 7, 12, and 23 weeks 4-NQO groups were respectively, 184 ± 88, 237 ± 105, and 329 ± 110. Thus, mutagenesis increased with length of exposure and post-treatment time. p-XSC modestly (ca. 15–30%) inhibited mutagenesis under all conditions. The inhibition reached significance at the last time point. When p-XSC was administered after 4-NQO, the MF was also modestly reduced. In 4-NQO-alone animals, levels of p53 in tongue (determined by Western blotting) were 1, 1.5 and 2.4 control levels at 10, 15 and 23 weeks, respectively. In the p-XSC + 4-NQO group, the enhancement in p53 levels by 4-NQO treatment was decreased about 90% at 15 weeks and 45% (P < 0.05) at 23 weeks, and by slightly smaller percentages in corresponding post-treatment groups. p-XSC alone did not alter p53 levels. As p53 levels generally increase in response to DNA damage, these results suggest that p-XSC reduces 4-NQO-induced DNA damage, resulting in reduced 4-NQO-induced mutagenesis and carcinogenesis. However, the fact that p-XSC is also effective when administered after 4-NQO, suggests additional mechanisms of inhibition exist." @default.
• W2015347798 created "2016-06-24" @default.
• W2015347798 creator A5008806631 @default.
• W2015347798 creator A5014971104 @default.
• W2015347798 creator A5023352512 @default.
• W2015347798 creator A5031364323 @default.
• W2015347798 creator A5048058203 @default.
• W2015347798 creator A5050067596 @default.
• W2015347798 creator A5065216537 @default.
• W2015347798 creator A5072656505 @default.
• W2015347798 creator A5080527856 @default.
• W2015347798 creator A5082424937 @default.
• W2015347798 creator A5083262817 @default.
• W2015347798 date "2007-12-01" @default.
• W2015347798 modified "2023-10-16" @default.
• W2015347798 title "Effects of 1,4-phenylenebis(methylene)selenocyanate on mutagenesis and p53 protein expression in the tongue of lacI rats treated with 4-nitroquinoline-N-oxide" @default.
• W2015347798 cites W1552426876 @default.
• W2015347798 cites W1677141414 @default.
• W2015347798 cites W1788218796 @default.
• W2015347798 cites W186393050 @default.
• W2015347798 cites W1865108599 @default.
• W2015347798 cites W1890730896 @default.
• W2015347798 cites W1948368576 @default.
• W2015347798 cites W1963592300 @default.
• W2015347798 cites W1975254957 @default.
• W2015347798 cites W1986914355 @default.
• W2015347798 cites W1991765557 @default.
• W2015347798 cites W1994228268 @default.
• W2015347798 cites W1995414069 @default.
• W2015347798 cites W2006504976 @default.
• W2015347798 cites W2006802772 @default.
• W2015347798 cites W2010903131 @default.
• W2015347798 cites W2013533973 @default.
• W2015347798 cites W2016795212 @default.
• W2015347798 cites W2017480444 @default.
• W2015347798 cites W2027666622 @default.
• W2015347798 cites W2030195733 @default.
• W2015347798 cites W2034117478 @default.
• W2015347798 cites W2040504917 @default.
• W2015347798 cites W2042316019 @default.
• W2015347798 cites W2048497033 @default.
• W2015347798 cites W2059072983 @default.
• W2015347798 cites W2062833467 @default.
• W2015347798 cites W2072933771 @default.
• W2015347798 cites W2078899066 @default.
• W2015347798 cites W2088937674 @default.
• W2015347798 cites W2091796448 @default.
• W2015347798 cites W2099006086 @default.
• W2015347798 cites W2104901487 @default.
• W2015347798 cites W2105737000 @default.
• W2015347798 cites W2106787323 @default.
• W2015347798 cites W2108197743 @default.
• W2015347798 cites W2118552069 @default.
• W2015347798 cites W2131910049 @default.
• W2015347798 cites W2132224561 @default.
• W2015347798 cites W2139430357 @default.
• W2015347798 cites W2143404712 @default.
• W2015347798 cites W2166709488 @default.
• W2015347798 cites W2170229434 @default.
• W2015347798 cites W2312732552 @default.
• W2015347798 cites W2354872070 @default.
• W2015347798 cites W355826115 @default.
• W2015347798 doi "https://doi.org/10.1016/j.mrgentox.2007.07.005" @default.
• W2015347798 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2700054" @default.
• W2015347798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17720616" @default.
• W2015347798 hasPublicationYear "2007" @default.
• W2015347798 type Work @default.
• W2015347798 sameAs 2015347798 @default.
• W2015347798 citedByCount "12" @default.
• W2015347798 countsByYear W20153477982012 @default.
• W2015347798 countsByYear W20153477982014 @default.
• W2015347798 countsByYear W20153477982015 @default.
• W2015347798 countsByYear W20153477982017 @default.
• W2015347798 countsByYear W20153477982018 @default.
• W2015347798 countsByYear W20153477982022 @default.
• W2015347798 crossrefType "journal-article" @default.
• W2015347798 hasAuthorship W2015347798A5008806631 @default.
• W2015347798 hasAuthorship W2015347798A5014971104 @default.
• W2015347798 hasAuthorship W2015347798A5023352512 @default.
• W2015347798 hasAuthorship W2015347798A5031364323 @default.
• W2015347798 hasAuthorship W2015347798A5048058203 @default.
• W2015347798 hasAuthorship W2015347798A5050067596 @default.
• W2015347798 hasAuthorship W2015347798A5065216537 @default.
• W2015347798 hasAuthorship W2015347798A5072656505 @default.
• W2015347798 hasAuthorship W2015347798A5080527856 @default.
• W2015347798 hasAuthorship W2015347798A5082424937 @default.
• W2015347798 hasAuthorship W2015347798A5083262817 @default.
• W2015347798 hasBestOaLocation W20153477982 @default.
• W2015347798 hasConcept C104317684 @default.
• W2015347798 hasConcept C143065580 @default.
• W2015347798 hasConcept C153911025 @default.
• W2015347798 hasConcept C16318435 @default.
• W2015347798 hasConcept C185592680 @default.
• W2015347798 hasConcept C2779911484 @default.
• W2015347798 hasConcept C55493867 @default.
• W2015347798 hasConcept C555283112 @default.
• W2015347798 hasConcept C86803240 @default.
• W2015347798 hasConceptScore W2015347798C104317684 @default.

• next