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- W2015352587 abstract "Abstract The chronic myeloid disorders are typically divided into myelodysplastic syndromes (MDS) and myeloproliferative disorders (MPD). However, there are a group of disorders with overlapping features of MDS and MPD. The World Health Organization has recently reclassified hematologic disorders and included a category of MDS/MPD overlap syndromes, which include chronic myelomonocytic leukemia, atypical chronic myelogenous leukemia, juvenile myelomonocytic leukemia, and MDS/MPD unclassifiable, which includes the provisional entity refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T). These latter 4 disorders remain largely enigmatic in their pathogenesis, have a poor prognosis, and limited therapeutic options. However, the JAK2 -V617F mutation has recently been discovered in a large majority of patients with RARS-T and might have future therapeutic implications. The approach to the management of these MDS/MPD overlap syndromes largely relies on extrapolation from the management of other MDS and MPD disorders that are similar to the MDS/MPD overlap syndromes." @default.
- W2015352587 created "2016-06-24" @default.
- W2015352587 creator A5085360755 @default.
- W2015352587 date "2006-12-01" @default.
- W2015352587 modified "2023-09-23" @default.
- W2015352587 title "Myelodysplastic/Myeloproliferative Disorder Overlap Syndrome: How Should it be Approached?" @default.
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- W2015352587 doi "https://doi.org/10.3816/clk.2006.n.014" @default.
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