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- W2015352743 abstract "Falls are a common geriatric syndrome and are the third leading cause of chronic disability worldwide. Key falls risk factors include impaired physical function, such as impaired balance, and cognitive decline. It is now recognized that even subtle changes in neurocognitive function are associated with increased falls risk. Recent neuroimaging studies demonstrate that impaired cognitive function is associated with disruptions in functional connectivity of large-scale networks within the brain. However, we have little understanding of the relationship between functional connectivity and mobility. Our previous pilot study (n=9) demonstrated that older fallers have disrupted network connectivity within the default mode network (DMN) - an age-sensitive neural network that is highly relevant to Alzheimer's disease. In a 12-month prospective study, we extended our investigation on the relationship between functional connectivity, mobility, and cognitive function. We aimed to determine: 1) whether there were difference in between- and within-network differences between fallers and non-fallers; and 2) whether these differences are associated with changes in cognitive performance and mobility over a 12-month period. A 12-month prospective fMRI study with 44 community-dwelling seniors between the ages of 70 to 80 year; 21 fallers (with history of ≥ 2 falls in last 12 months) and 23 non-fallers (≤1 fall in the last 12 months). Participants performed a finger tapping task during fMRI scanning. Clinical measures of mobility and executive functions were assessed at baseline and 12 months. Fallers showed decreased connectivity between the fronto-parietal network (FP) and the motor network (Mot); and increased connectivity between the DMN and FP. No significant differences were found within the networks. Baseline connectivity between Mot-FP was associated with change in Short Physical Performance Battery score and change in Stroop Test score. Compared with non-fallers, older fallers demonstrated disrupted between-network functional connectivity. Critically, greater disruptions at baseline were significantly associated with greater decline in both mobility and executive functions over a 12-month period. Our results suggest that a history of falls may be an early biomarker of r isk for cognitive decline and impaired mobility. Furthermore, between-network connectivity disruption may precede within-network connectivity with age and neurodegeneration." @default.
- W2015352743 created "2016-06-24" @default.
- W2015352743 creator A5076632833 @default.
- W2015352743 date "2013-07-01" @default.
- W2015352743 modified "2023-09-27" @default.
- W2015352743 title "O5-03-05: An early biomarker of functional disconnectivity and subsequent cognitive decline" @default.
- W2015352743 doi "https://doi.org/10.1016/j.jalz.2013.04.485" @default.
- W2015352743 hasPublicationYear "2013" @default.
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