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- W2015355511 abstract "Variable (diversity) joining [V(D)J] recombination of immune gene loci proceeds in an ordered manner with D to J portions recombining first and then an upstream V joins that recombinant. We present evidence that the non-core domain of recombination activating gene (RAG) protein 2 is involved in the regulation of recombinatorial order. In mice lacking the non-core domain of RAG2 the ordered rearrangement is disturbed and direct V to D rearrangements are 10- to 1000-times increased in tri-partite immune gene loci. Some forms of inter-chromosomal translocations between TCRbeta and TCRdelta D gene segments are also increased in the core RAG2 animals as compared with their wild-type (WT) counterparts. In addition, the concise use of proper recombination signal sequences (RSSs) appears to be disturbed in the core RAG2 mice as compared with WT RAG2 animals." @default.
- W2015355511 created "2016-06-24" @default.
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- W2015355511 date "2008-09-06" @default.
- W2015355511 modified "2023-10-02" @default.
- W2015355511 title "RAG2's non-core domain contributes to the ordered regulation of V(D)J recombination" @default.
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- W2015355511 doi "https://doi.org/10.1093/nar/gkn553" @default.
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