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- W2015359849 startingPage "1038" @default.
- W2015359849 abstract "The charge of a DNA molecule is a crucial parameter in many DNA detection and manipulation schemes such as gel electrophoresis and lab-on-a-chip applications. Here, we study the partial reduction of the DNA charge due to counterion binding by means of nanopore translocation experiments and all-atom molecular dynamics (MD) simulations. Surprisingly, we find that the translocation time of a DNA molecule through a solid-state nanopore strongly increases as the counterions decrease in size from K(+) to Na(+) to Li(+), both for double-stranded DNA (dsDNA) and single-stranded DNA (ssDNA). MD simulations elucidate the microscopic origin of this effect: Li(+) and Na(+) bind DNA stronger than K(+). These fundamental insights into the counterion binding to DNA also provide a practical method for achieving at least 10-fold enhanced resolution in nanopore applications." @default.
- W2015359849 created "2016-06-24" @default.
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- W2015359849 date "2012-01-27" @default.
- W2015359849 modified "2023-10-01" @default.
- W2015359849 title "Slowing down DNA Translocation through a Nanopore in Lithium Chloride" @default.
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- W2015359849 doi "https://doi.org/10.1021/nl204273h" @default.
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