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- W2015360854 abstract "ISEE-151 Introduction: Epidermal growth factor is associated with the occurrence of various cancers, including those of the skin, lung, urinary bladder, prostate, breast, and stomach. Therefore, epidermal growth factor receptor (EGFR) may be used as a biomarker of malignancies. However, its association with liver cancer has not been extensively studied. We conducted a study in an endemic area of liver cancer to evaluate whether serum EGFR may increase in patients of liver cancer. Methods: We recruited 100 patients of liver cancer and 100 age- and sex-matched controls from two hospitals in southern Taiwan from June 2000 to April 2002. The incidence of liver cancer in this area is high because of environmental factors such as viral hepatitis. The levels of EGFR in sera were determined by enzyme-linked immunosorbent assay (ELISA). Results: A significant higher serum EGFR level was observed among patients (668.1 vs. 243.1 fmol/mL, p<0.01). After adjusting for history of hepatitis B and C through multiple regression, patients still had an average serum EGFR level 406.1 fmol/mL higher than that of controls (p<0.01). Discussion: We concluded that EGFR is over-expressed in patients of liver cancer, and therefore, serum EGFR level is a potential biomarker of liver cancer. In particular, it is increased in patients of liver cancers not related to viral hepatitis and thus might be a biomarker of liver cancer caused by other environmental pollutants. Further studies should be conducted to define the role of EGFR in the development of liver cancer and identify environmental factors that may cause liver cancer through pathways related to the activation of EGFR." @default.
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- W2015360854 date "2004-07-01" @default.
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- W2015360854 title "SERUM LEVEL OF EPIDERMAL GROWTH FACTOR RECEPTOR AS A BIOMARKER OF LIVER CANCER" @default.
- W2015360854 doi "https://doi.org/10.1097/00001648-200407000-00174" @default.
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