FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015362019> ?p ?o ?g. }

• W2015362019 endingPage "e67063" @default.
• W2015362019 startingPage "e67063" @default.
• W2015362019 abstract "The inflammatory response following ischemic stroke is dominated by innate immune cells: resident microglia and blood-derived macrophages. The ambivalent role of these cells in stroke outcome might be explained in part by the acquisition of distinct functional phenotypes: classically (M1) and alternatively activated (M2) macrophages. To shed light on the crosstalk between hypoxic neurons and macrophages, an in vitro model was set up in which bone marrow-derived macrophages were co-cultured with hippocampal slices subjected to oxygen and glucose deprivation. The results showed that macrophages provided potent protection against neuron cell loss through a paracrine mechanism, and that they expressed M2-type alternative polarization. These findings raised the possibility of using bone marrow-derived M2 macrophages in cellular therapy for stroke. Therefore, 2 million M2 macrophages (or vehicle) were intravenously administered during the subacute stage of ischemia (D4) in a model of transient middle cerebral artery occlusion. Functional neuroscores and magnetic resonance imaging endpoints (infarct volumes, blood-brain barrier integrity, phagocytic activity assessed by iron oxide uptake) were longitudinally monitored for 2 weeks. This cell-based treatment did not significantly improve any outcome measure compared with vehicle, suggesting that this strategy is not relevant to stroke therapy." @default.
• W2015362019 created "2016-06-24" @default.
• W2015362019 creator A5001846686 @default.
• W2015362019 creator A5007558671 @default.
• W2015362019 creator A5016604848 @default.
• W2015362019 creator A5024297044 @default.
• W2015362019 creator A5035929683 @default.
• W2015362019 creator A5048979802 @default.
• W2015362019 creator A5049975927 @default.
• W2015362019 creator A5058590923 @default.
• W2015362019 creator A5061141183 @default.
• W2015362019 creator A5065112879 @default.
• W2015362019 creator A5066664843 @default.
• W2015362019 creator A5067440768 @default.
• W2015362019 creator A5081894683 @default.
• W2015362019 creator A5087710458 @default.
• W2015362019 creator A5089510795 @default.
• W2015362019 date "2013-06-25" @default.
• W2015362019 modified "2023-10-15" @default.
• W2015362019 title "In Vitro and In Vivo Models of Cerebral Ischemia Show Discrepancy in Therapeutic Effects of M2 Macrophages" @default.
• W2015362019 cites W1797422316 @default.
• W2015362019 cites W1825325706 @default.
• W2015362019 cites W1975631820 @default.
• W2015362019 cites W1986736465 @default.
• W2015362019 cites W1994334993 @default.
• W2015362019 cites W2001717792 @default.
• W2015362019 cites W2001952628 @default.
• W2015362019 cites W2018820918 @default.
• W2015362019 cites W2023749167 @default.
• W2015362019 cites W2034865298 @default.
• W2015362019 cites W2035221144 @default.
• W2015362019 cites W2035832233 @default.
• W2015362019 cites W2049201207 @default.
• W2015362019 cites W2080638375 @default.
• W2015362019 cites W2083946660 @default.
• W2015362019 cites W2086464763 @default.
• W2015362019 cites W2093705034 @default.
• W2015362019 cites W2095315362 @default.
• W2015362019 cites W2112505121 @default.
• W2015362019 cites W2116226263 @default.
• W2015362019 cites W2118200665 @default.
• W2015362019 cites W2119607029 @default.
• W2015362019 cites W2122031395 @default.
• W2015362019 cites W2130529018 @default.
• W2015362019 cites W2134729461 @default.
• W2015362019 cites W2135285893 @default.
• W2015362019 cites W2142808413 @default.
• W2015362019 cites W90671291 @default.
• W2015362019 doi "https://doi.org/10.1371/journal.pone.0067063" @default.
• W2015362019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3692438" @default.
• W2015362019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23825621" @default.
• W2015362019 hasPublicationYear "2013" @default.
• W2015362019 type Work @default.
• W2015362019 sameAs 2015362019 @default.
• W2015362019 citedByCount "41" @default.
• W2015362019 countsByYear W20153620192014 @default.
• W2015362019 countsByYear W20153620192015 @default.
• W2015362019 countsByYear W20153620192016 @default.
• W2015362019 countsByYear W20153620192017 @default.
• W2015362019 countsByYear W20153620192018 @default.
• W2015362019 countsByYear W20153620192020 @default.
• W2015362019 countsByYear W20153620192021 @default.
• W2015362019 countsByYear W20153620192022 @default.
• W2015362019 crossrefType "journal-article" @default.
• W2015362019 hasAuthorship W2015362019A5001846686 @default.
• W2015362019 hasAuthorship W2015362019A5007558671 @default.
• W2015362019 hasAuthorship W2015362019A5016604848 @default.
• W2015362019 hasAuthorship W2015362019A5024297044 @default.
• W2015362019 hasAuthorship W2015362019A5035929683 @default.
• W2015362019 hasAuthorship W2015362019A5048979802 @default.
• W2015362019 hasAuthorship W2015362019A5049975927 @default.
• W2015362019 hasAuthorship W2015362019A5058590923 @default.
• W2015362019 hasAuthorship W2015362019A5061141183 @default.
• W2015362019 hasAuthorship W2015362019A5065112879 @default.
• W2015362019 hasAuthorship W2015362019A5066664843 @default.
• W2015362019 hasAuthorship W2015362019A5067440768 @default.
• W2015362019 hasAuthorship W2015362019A5081894683 @default.
• W2015362019 hasAuthorship W2015362019A5087710458 @default.
• W2015362019 hasAuthorship W2015362019A5089510795 @default.
• W2015362019 hasBestOaLocation W20153620191 @default.
• W2015362019 hasConcept C126322002 @default.
• W2015362019 hasConcept C127413603 @default.
• W2015362019 hasConcept C136449434 @default.
• W2015362019 hasConcept C142724271 @default.
• W2015362019 hasConcept C148762608 @default.
• W2015362019 hasConcept C150903083 @default.
• W2015362019 hasConcept C160448771 @default.
• W2015362019 hasConcept C203014093 @default.
• W2015362019 hasConcept C207001950 @default.
• W2015362019 hasConcept C2776914184 @default.
• W2015362019 hasConcept C2779830541 @default.
• W2015362019 hasConcept C2780007613 @default.
• W2015362019 hasConcept C2780645631 @default.
• W2015362019 hasConcept C541997718 @default.
• W2015362019 hasConcept C71924100 @default.
• W2015362019 hasConcept C78519656 @default.
• W2015362019 hasConcept C86803240 @default.
• W2015362019 hasConcept C8891405 @default.

• next