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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015362806> ?p ?o ?g. }

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• W2015362806 abstract "<i>Background:</i> Epigenetic alteration through methylation is one of the most important steps in carcinogenesis. However, the relation between hepatitis virus infection and epigenetic alterations is poorly understood. <i>Methods:</i> Sixteen patients without hepatitis B virus (HBV) and hepatitis C virus (HCV) and 35 patients with HBV or HCV who underwent liver resection for hepatocellular carcinoma (HCC) were studied. Mutation of <i>p53</i> was detected by direct sequencing. Methylation status of <i>p16</i> was evaluated in tumor and noncancerous liver tissues by methylation-specific polymerase chain reaction. <i>Results:</i> In HCC without HBV and HCV, <i>p53</i> mutations were detected in 5 (31%) of 16 HCCs. Methylation of <i>p16</i> promoter was detected in 2 (25%) of 8 moderately differentiated HCCs, 6 (75%) of 8 poorly differentiated HCCs, and none of 16 noncancerous tissue specimens. In HCC with HBV or HCV, <i>p53</i> mutations were detected in 8 (23%) of 35 HCCs. Methylation of <i>p16</i> promoter was detected in 2 (100%) of 2 well-differentiated HCCs, 13 (76%) of 17 moderately differentiated HCCs, 12 (75%) of 16 poorly differentiated HCCs, and 9 (26%) of 35 noncancerous liver tissue specimens. <i>Conclusions:</i> Our results suggest that hepatitis viruses might induce methylation of <i>p16</i> promoter in liver with chronic inflammation, before appearance of HCC." @default.
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• W2015362806 date "2004-01-01" @default.
• W2015362806 modified "2023-09-24" @default.
• W2015362806 title "<i>p16</i> Promoter Hypermethylation in Human Hepatocellular Carcinoma with or without Hepatitis Virus Infection" @default.
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• W2015362806 doi "https://doi.org/10.1159/000076639" @default.
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