FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015366648> ?p ?o ?g. }

• W2015366648 endingPage "3768" @default.
• W2015366648 startingPage "3759" @default.
• W2015366648 abstract "Tyrosine phosphorylation of paxillin regulates actin cytoskeleton-dependent changes in cell morphology and motility in adherent cells. In this report we investigated the involvement of paxillin tyrosine phosphorylation in the regulation of actin cytoskeleton-dependent polarization and motility of a non-adherent IL-3-dependent murine pre-B lymphocytic cell line Baf3. We also assessed the effect of phorbol myristate acetate (PMA), a phorbol ester analogous to those currently in clinical trials for the treatment of leukemia, on paxillin phosphorylation. Using tyrosine-to-phenylalanine phosphorylation mutants of paxillin and phosphospecific antibody we demonstrated that IL-3 stimulated phosphorylation of paxillin tyrosine residues 31 and 118, whereas the tyrosines 40 and 181 were constitutively phosphorylated. Phosphorylation of paxillin residues 31 and 118 was required for cell polarization and motility. In the presence of IL-3, PMA dramatically reduced the phosphorylation of residues 31 and 118, which was accompanied by inhibition of cell polarization and motility. This PMA effect was partially recapitulated by expression of exogenous tyrosine 31 and 118 mutants of paxillin. We also demonstrated that PMA inhibited the IL-3-induced and activation-dependent tyrosine phosphorylation of focal adhesion kinase. Thus, our results indicate that phosphorylation of paxillin tyrosine residues 31 and 118 regulates actin-dependent polarization and motility of pre-B Baf3 cells, both of which could be inhibited by PMA. They also suggest that inhibition of upstream signaling by PMA contributes to the decrease of paxillin phosphorylation and subsequent changes in cell morphology." @default.
• W2015366648 created "2016-06-24" @default.
• W2015366648 creator A5000830028 @default.
• W2015366648 creator A5015886026 @default.
• W2015366648 creator A5045764409 @default.
• W2015366648 creator A5054181293 @default.
• W2015366648 creator A5059239306 @default.
• W2015366648 creator A5083947422 @default.
• W2015366648 date "2004-08-01" @default.
• W2015366648 modified "2023-10-17" @default.
• W2015366648 title "Phosphorylation of paxillin tyrosines 31 and 118 controls polarization and motility of lymphoid cells and is PMA-sensitive" @default.
• W2015366648 cites W1516960913 @default.
• W2015366648 cites W1578582539 @default.
• W2015366648 cites W1592294255 @default.
• W2015366648 cites W1592758533 @default.
• W2015366648 cites W1605140126 @default.
• W2015366648 cites W1950041808 @default.
• W2015366648 cites W1969689864 @default.
• W2015366648 cites W1990902731 @default.
• W2015366648 cites W1991682096 @default.
• W2015366648 cites W1997468256 @default.
• W2015366648 cites W2011001118 @default.
• W2015366648 cites W2015234052 @default.
• W2015366648 cites W2022157262 @default.
• W2015366648 cites W2022541364 @default.
• W2015366648 cites W2029723738 @default.
• W2015366648 cites W2032963219 @default.
• W2015366648 cites W2053356200 @default.
• W2015366648 cites W2055354269 @default.
• W2015366648 cites W2058170261 @default.
• W2015366648 cites W2060141022 @default.
• W2015366648 cites W2061229454 @default.
• W2015366648 cites W2066909100 @default.
• W2015366648 cites W2073513388 @default.
• W2015366648 cites W2076457965 @default.
• W2015366648 cites W2082668870 @default.
• W2015366648 cites W2085294978 @default.
• W2015366648 cites W2089991028 @default.
• W2015366648 cites W2090901060 @default.
• W2015366648 cites W2100807457 @default.
• W2015366648 cites W2107552761 @default.
• W2015366648 cites W2113001027 @default.
• W2015366648 cites W2117040422 @default.
• W2015366648 cites W2118030635 @default.
• W2015366648 cites W2120346794 @default.
• W2015366648 cites W2122875377 @default.
• W2015366648 cites W2140506935 @default.
• W2015366648 cites W2154524184 @default.
• W2015366648 cites W2159972238 @default.
• W2015366648 cites W2169787574 @default.
• W2015366648 cites W4233478018 @default.
• W2015366648 cites W4240762858 @default.
• W2015366648 cites W4253357698 @default.
• W2015366648 doi "https://doi.org/10.1242/jcs.01206" @default.
• W2015366648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15252114" @default.
• W2015366648 hasPublicationYear "2004" @default.
• W2015366648 type Work @default.
• W2015366648 sameAs 2015366648 @default.
• W2015366648 citedByCount "27" @default.
• W2015366648 countsByYear W20153666482012 @default.
• W2015366648 countsByYear W20153666482013 @default.
• W2015366648 countsByYear W20153666482014 @default.
• W2015366648 countsByYear W20153666482015 @default.
• W2015366648 countsByYear W20153666482018 @default.
• W2015366648 countsByYear W20153666482019 @default.
• W2015366648 countsByYear W20153666482020 @default.
• W2015366648 crossrefType "journal-article" @default.
• W2015366648 hasAuthorship W2015366648A5000830028 @default.
• W2015366648 hasAuthorship W2015366648A5015886026 @default.
• W2015366648 hasAuthorship W2015366648A5045764409 @default.
• W2015366648 hasAuthorship W2015366648A5054181293 @default.
• W2015366648 hasAuthorship W2015366648A5059239306 @default.
• W2015366648 hasAuthorship W2015366648A5083947422 @default.
• W2015366648 hasConcept C108391706 @default.
• W2015366648 hasConcept C116581196 @default.
• W2015366648 hasConcept C11960822 @default.
• W2015366648 hasConcept C142669718 @default.
• W2015366648 hasConcept C1491633281 @default.
• W2015366648 hasConcept C151166631 @default.
• W2015366648 hasConcept C153911025 @default.
• W2015366648 hasConcept C195794163 @default.
• W2015366648 hasConcept C2776165026 @default.
• W2015366648 hasConcept C2777553839 @default.
• W2015366648 hasConcept C55493867 @default.
• W2015366648 hasConcept C58207958 @default.
• W2015366648 hasConcept C86803240 @default.
• W2015366648 hasConcept C90934575 @default.
• W2015366648 hasConcept C95444343 @default.
• W2015366648 hasConceptScore W2015366648C108391706 @default.
• W2015366648 hasConceptScore W2015366648C116581196 @default.
• W2015366648 hasConceptScore W2015366648C11960822 @default.
• W2015366648 hasConceptScore W2015366648C142669718 @default.
• W2015366648 hasConceptScore W2015366648C1491633281 @default.
• W2015366648 hasConceptScore W2015366648C151166631 @default.
• W2015366648 hasConceptScore W2015366648C153911025 @default.
• W2015366648 hasConceptScore W2015366648C195794163 @default.
• W2015366648 hasConceptScore W2015366648C2776165026 @default.
• W2015366648 hasConceptScore W2015366648C2777553839 @default.

• next