FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015366945> ?p ?o ?g. }

• W2015366945 endingPage "378" @default.
• W2015366945 startingPage "365" @default.
• W2015366945 abstract "Purpose To determine whether intravenous administration of Astenose, a high-molecular-weight nonanticoagulant heparin, can reduce restenosis following balloon angioplasty in a rabbit model. Materials and Methods Focal atherosclerosis was induced in 54 rabbits (89 vessels), and angioplasty was performed after animals were randomized into five groups. Group 1 vessels (control) were treated with lactated Ringer solution for 28 days (n = 19); group 2, Astenose at 0.10 mg/kg per hour for 28 days (n = 16); group 3, Astenose at 0.33 mg/kg per hour for 28 days (n = 16); group 4, Astenose at 0.60 mg/kg per hour for 28 days (n = 17); and group 5, Astenose at 0.33 mg/kg per hour for 14 days (n = 21). Arteriograms were obtained to measure minimal luminal diameters before, immediately after, and 28 days after angioplasty, and the rabbits were killed for histologic analysis. Results Angiographically demonstrated restenosis was significantly reduced in groups 3 (18.9% ± 3.7, P = .04) and 4 (20.2% ± 3.1, P = .04) compared with the control group (32.4% ± 4.8). Group 5 showed a nonsignificant trend toward reduced restenosis (23.1% ± 2.9, P = .09), and group 2 showed restenosis similar to that in group 1 (31.0% ± 2.5, P = .80). However, quantitative histopathologic analysis detected no differences among the groups in absolute plaque area. Medial area was significantly smaller in groups 2 and 5 (P ≤ .002) than in group 1, and there was a nonsignificant trend toward reduced medial area in groups 3 and 4 (P = .12). Conclusion Long-term intravenous Astenose therapy resulted in a modest but statistically significant reduction in angiographically demonstrated restenosis after angioplasty in this atherosclerotic rabbit model. To determine whether intravenous administration of Astenose, a high-molecular-weight nonanticoagulant heparin, can reduce restenosis following balloon angioplasty in a rabbit model. Focal atherosclerosis was induced in 54 rabbits (89 vessels), and angioplasty was performed after animals were randomized into five groups. Group 1 vessels (control) were treated with lactated Ringer solution for 28 days (n = 19); group 2, Astenose at 0.10 mg/kg per hour for 28 days (n = 16); group 3, Astenose at 0.33 mg/kg per hour for 28 days (n = 16); group 4, Astenose at 0.60 mg/kg per hour for 28 days (n = 17); and group 5, Astenose at 0.33 mg/kg per hour for 14 days (n = 21). Arteriograms were obtained to measure minimal luminal diameters before, immediately after, and 28 days after angioplasty, and the rabbits were killed for histologic analysis. Angiographically demonstrated restenosis was significantly reduced in groups 3 (18.9% ± 3.7, P = .04) and 4 (20.2% ± 3.1, P = .04) compared with the control group (32.4% ± 4.8). Group 5 showed a nonsignificant trend toward reduced restenosis (23.1% ± 2.9, P = .09), and group 2 showed restenosis similar to that in group 1 (31.0% ± 2.5, P = .80). However, quantitative histopathologic analysis detected no differences among the groups in absolute plaque area. Medial area was significantly smaller in groups 2 and 5 (P ≤ .002) than in group 1, and there was a nonsignificant trend toward reduced medial area in groups 3 and 4 (P = .12). Long-term intravenous Astenose therapy resulted in a modest but statistically significant reduction in angiographically demonstrated restenosis after angioplasty in this atherosclerotic rabbit model." @default.
• W2015366945 created "2016-06-24" @default.
• W2015366945 creator A5037911272 @default.
• W2015366945 creator A5039803568 @default.
• W2015366945 creator A5091573400 @default.
• W2015366945 date "1995-05-01" @default.
• W2015366945 modified "2023-10-06" @default.
• W2015366945 title "Effect of Nonanticoagulant Heparin (Astenose) on Restenosis after Balloon Angioplasty in the Atherosclerotic Rabbit" @default.
• W2015366945 cites W153662504 @default.
• W2015366945 cites W1964502955 @default.
• W2015366945 cites W1965632673 @default.
• W2015366945 cites W1965967389 @default.
• W2015366945 cites W1972632639 @default.
• W2015366945 cites W1974440307 @default.
• W2015366945 cites W1977798903 @default.
• W2015366945 cites W1978592486 @default.
• W2015366945 cites W1979075770 @default.
• W2015366945 cites W1979523500 @default.
• W2015366945 cites W1980938471 @default.
• W2015366945 cites W1981647960 @default.
• W2015366945 cites W1984920885 @default.
• W2015366945 cites W1985069397 @default.
• W2015366945 cites W1987653036 @default.
• W2015366945 cites W1987939902 @default.
• W2015366945 cites W1989456091 @default.
• W2015366945 cites W1998549621 @default.
• W2015366945 cites W2003281540 @default.
• W2015366945 cites W2011429978 @default.
• W2015366945 cites W2014351431 @default.
• W2015366945 cites W2017068398 @default.
• W2015366945 cites W2018495714 @default.
• W2015366945 cites W2021851372 @default.
• W2015366945 cites W2024500935 @default.
• W2015366945 cites W2026581670 @default.
• W2015366945 cites W2029566146 @default.
• W2015366945 cites W2033354476 @default.
• W2015366945 cites W2036203635 @default.
• W2015366945 cites W2036296217 @default.
• W2015366945 cites W2040614895 @default.
• W2015366945 cites W2049478963 @default.
• W2015366945 cites W2051904824 @default.
• W2015366945 cites W2055366835 @default.
• W2015366945 cites W2071192954 @default.
• W2015366945 cites W2073923473 @default.
• W2015366945 cites W2078563992 @default.
• W2015366945 cites W2078765684 @default.
• W2015366945 cites W2082458333 @default.
• W2015366945 cites W2086056626 @default.
• W2015366945 cites W2092972260 @default.
• W2015366945 cites W2096668470 @default.
• W2015366945 cites W2107392339 @default.
• W2015366945 cites W2118313992 @default.
• W2015366945 cites W2127145200 @default.
• W2015366945 cites W2128781299 @default.
• W2015366945 cites W2130054896 @default.
• W2015366945 cites W2130075870 @default.
• W2015366945 cites W2137114048 @default.
• W2015366945 cites W2146087721 @default.
• W2015366945 cites W2153852857 @default.
• W2015366945 cites W2153935195 @default.
• W2015366945 cites W2155291282 @default.
• W2015366945 cites W2159642184 @default.
• W2015366945 cites W216844364 @default.
• W2015366945 cites W2277146921 @default.
• W2015366945 cites W2323785475 @default.
• W2015366945 cites W2338023005 @default.
• W2015366945 cites W2338633505 @default.
• W2015366945 cites W2341350186 @default.
• W2015366945 cites W2411722752 @default.
• W2015366945 cites W2412059862 @default.
• W2015366945 cites W2417948955 @default.
• W2015366945 cites W2418412032 @default.
• W2015366945 cites W2888813343 @default.
• W2015366945 cites W3152355165 @default.
• W2015366945 cites W3784027 @default.
• W2015366945 cites W51309640 @default.
• W2015366945 cites W77699174 @default.
• W2015366945 doi "https://doi.org/10.1016/s1051-0443(95)72825-1" @default.
• W2015366945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7647438" @default.
• W2015366945 hasPublicationYear "1995" @default.
• W2015366945 type Work @default.
• W2015366945 sameAs 2015366945 @default.
• W2015366945 citedByCount "5" @default.
• W2015366945 countsByYear W20153669452012 @default.
• W2015366945 crossrefType "journal-article" @default.
• W2015366945 hasAuthorship W2015366945A5037911272 @default.
• W2015366945 hasAuthorship W2015366945A5039803568 @default.
• W2015366945 hasAuthorship W2015366945A5091573400 @default.
• W2015366945 hasConcept C126322002 @default.
• W2015366945 hasConcept C126894567 @default.
• W2015366945 hasConcept C139059822 @default.
• W2015366945 hasConcept C141071460 @default.
• W2015366945 hasConcept C2777557582 @default.
• W2015366945 hasConcept C2778283817 @default.
• W2015366945 hasConcept C2778583881 @default.
• W2015366945 hasConcept C2780326628 @default.
• W2015366945 hasConcept C71924100 @default.
• W2015366945 hasConceptScore W2015366945C126322002 @default.

• next