FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015366993> ?p ?o ?g. }

• W2015366993 endingPage "510" @default.
• W2015366993 startingPage "505" @default.
• W2015366993 abstract "BackgroundThe inhaled corticosteroid (ICS)/long-acting β-agonist (LABA) combination inhaler has the potential to improve adherence with ICS therapy in asthma.ObjectiveTo determine whether ICS/LABA combination inhaler therapy improves adherence compared with separate inhaler use.MethodsIn a 24-week randomized controlled parallel group study, 111 subjects were prescribed 125 μg fluticasone dipropionate (FP) and 25 μg salmeterol, 2 actuations twice daily through either a combination inhaler or separate inhalers concurrently. Medication use was recorded by covert electronic monitors. The primary outcome variable was adherence during the final 6-week period, defined as the number of doses taken as a percentage of those prescribed.ResultsComplete adherence data from the final 6-week period were available for 49 and 54 subjects in the separate and combination groups, respectively. The mean (SD) adherence was 73.7% (36.0) for FP, 76.7% (30.5) for salmeterol, and 82.4% (24.5) for FP/salmeterol. There were no significant differences in adherence between FP/salmeterol and FP (–8.7%; 95% CI, –10.6 to 3.3) and salmeterol (–5.6%; 95% CI, –16.4 to 5.1). There was no significant difference in overuse among the FP, salmeterol, or FP/salmeterol groups. In 2 (4%) of 49 subjects, salmeterol was effectively taken as monotherapy during a 6-week period.ConclusionIn the setting of a randomized controlled trial, use of a combination ICS/LABA inhaler does not markedly increase adherence above that observed with separate inhaler use. LABA monotherapy was observed in a small proportion of patients prescribed ICS and LABA therapy via separate inhalers. The inhaled corticosteroid (ICS)/long-acting β-agonist (LABA) combination inhaler has the potential to improve adherence with ICS therapy in asthma. To determine whether ICS/LABA combination inhaler therapy improves adherence compared with separate inhaler use. In a 24-week randomized controlled parallel group study, 111 subjects were prescribed 125 μg fluticasone dipropionate (FP) and 25 μg salmeterol, 2 actuations twice daily through either a combination inhaler or separate inhalers concurrently. Medication use was recorded by covert electronic monitors. The primary outcome variable was adherence during the final 6-week period, defined as the number of doses taken as a percentage of those prescribed. Complete adherence data from the final 6-week period were available for 49 and 54 subjects in the separate and combination groups, respectively. The mean (SD) adherence was 73.7% (36.0) for FP, 76.7% (30.5) for salmeterol, and 82.4% (24.5) for FP/salmeterol. There were no significant differences in adherence between FP/salmeterol and FP (–8.7%; 95% CI, –10.6 to 3.3) and salmeterol (–5.6%; 95% CI, –16.4 to 5.1). There was no significant difference in overuse among the FP, salmeterol, or FP/salmeterol groups. In 2 (4%) of 49 subjects, salmeterol was effectively taken as monotherapy during a 6-week period. In the setting of a randomized controlled trial, use of a combination ICS/LABA inhaler does not markedly increase adherence above that observed with separate inhaler use. LABA monotherapy was observed in a small proportion of patients prescribed ICS and LABA therapy via separate inhalers." @default.
• W2015366993 created "2016-06-24" @default.
• W2015366993 creator A5000064307 @default.
• W2015366993 creator A5000853576 @default.
• W2015366993 creator A5010020824 @default.
• W2015366993 creator A5040905319 @default.
• W2015366993 creator A5050922990 @default.
• W2015366993 creator A5059164140 @default.
• W2015366993 date "2010-09-01" @default.
• W2015366993 modified "2023-10-17" @default.
• W2015366993 title "Randomized controlled trial of adherence with single or combination inhaled corticosteroid/long-acting β-agonist inhaler therapy in asthma" @default.
• W2015366993 cites W133981918 @default.
• W2015366993 cites W1963759527 @default.
• W2015366993 cites W1968405264 @default.
• W2015366993 cites W1991968623 @default.
• W2015366993 cites W1996454140 @default.
• W2015366993 cites W2009200551 @default.
• W2015366993 cites W2034087628 @default.
• W2015366993 cites W2040474452 @default.
• W2015366993 cites W2044202103 @default.
• W2015366993 cites W2047292362 @default.
• W2015366993 cites W2050107000 @default.
• W2015366993 cites W2051278840 @default.
• W2015366993 cites W2053351348 @default.
• W2015366993 cites W2062417667 @default.
• W2015366993 cites W2074714879 @default.
• W2015366993 cites W2081653422 @default.
• W2015366993 cites W2082824854 @default.
• W2015366993 cites W2099036273 @default.
• W2015366993 cites W2106573383 @default.
• W2015366993 cites W2107219724 @default.
• W2015366993 cites W2116899830 @default.
• W2015366993 cites W2124481948 @default.
• W2015366993 cites W2135466722 @default.
• W2015366993 cites W2138027296 @default.
• W2015366993 cites W2142653918 @default.
• W2015366993 cites W2147875154 @default.
• W2015366993 cites W2151712729 @default.
• W2015366993 cites W2153290820 @default.
• W2015366993 cites W2155830934 @default.
• W2015366993 cites W2160621537 @default.
• W2015366993 cites W2162590044 @default.
• W2015366993 cites W2169433957 @default.
• W2015366993 cites W2171333287 @default.
• W2015366993 doi "https://doi.org/10.1016/j.jaci.2010.06.033" @default.
• W2015366993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20816187" @default.
• W2015366993 hasPublicationYear "2010" @default.
• W2015366993 type Work @default.
• W2015366993 sameAs 2015366993 @default.
• W2015366993 citedByCount "29" @default.
• W2015366993 countsByYear W20153669932013 @default.
• W2015366993 countsByYear W20153669932014 @default.
• W2015366993 countsByYear W20153669932015 @default.
• W2015366993 countsByYear W20153669932016 @default.
• W2015366993 countsByYear W20153669932017 @default.
• W2015366993 countsByYear W20153669932020 @default.
• W2015366993 countsByYear W20153669932021 @default.
• W2015366993 countsByYear W20153669932022 @default.
• W2015366993 crossrefType "journal-article" @default.
• W2015366993 hasAuthorship W2015366993A5000064307 @default.
• W2015366993 hasAuthorship W2015366993A5000853576 @default.
• W2015366993 hasAuthorship W2015366993A5010020824 @default.
• W2015366993 hasAuthorship W2015366993A5040905319 @default.
• W2015366993 hasAuthorship W2015366993A5050922990 @default.
• W2015366993 hasAuthorship W2015366993A5059164140 @default.
• W2015366993 hasConcept C126322002 @default.
• W2015366993 hasConcept C168563851 @default.
• W2015366993 hasConcept C2776042228 @default.
• W2015366993 hasConcept C2776136866 @default.
• W2015366993 hasConcept C2776719499 @default.
• W2015366993 hasConcept C2776804153 @default.
• W2015366993 hasConcept C2776999253 @default.
• W2015366993 hasConcept C2777419714 @default.
• W2015366993 hasConcept C2779028295 @default.
• W2015366993 hasConcept C2779871671 @default.
• W2015366993 hasConcept C2780261241 @default.
• W2015366993 hasConcept C2780667556 @default.
• W2015366993 hasConcept C2781212218 @default.
• W2015366993 hasConcept C42219234 @default.
• W2015366993 hasConcept C71924100 @default.
• W2015366993 hasConceptScore W2015366993C126322002 @default.
• W2015366993 hasConceptScore W2015366993C168563851 @default.
• W2015366993 hasConceptScore W2015366993C2776042228 @default.
• W2015366993 hasConceptScore W2015366993C2776136866 @default.
• W2015366993 hasConceptScore W2015366993C2776719499 @default.
• W2015366993 hasConceptScore W2015366993C2776804153 @default.
• W2015366993 hasConceptScore W2015366993C2776999253 @default.
• W2015366993 hasConceptScore W2015366993C2777419714 @default.
• W2015366993 hasConceptScore W2015366993C2779028295 @default.
• W2015366993 hasConceptScore W2015366993C2779871671 @default.
• W2015366993 hasConceptScore W2015366993C2780261241 @default.
• W2015366993 hasConceptScore W2015366993C2780667556 @default.
• W2015366993 hasConceptScore W2015366993C2781212218 @default.
• W2015366993 hasConceptScore W2015366993C42219234 @default.
• W2015366993 hasConceptScore W2015366993C71924100 @default.
• W2015366993 hasIssue "3" @default.
• W2015366993 hasLocation W20153669931 @default.
• W2015366993 hasLocation W20153669932 @default.

• next