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- W2015375534 abstract "The effects of various (1-->3)-beta-D-glucans on hematopoietic responses of mice were investigated by measuring colony stimulating activity in sera and ascites of the mice administered glucan. We have demonstrated that the hematopoietic response was increased by various structures of (1-->3)-beta-D-glucans, i.e. soluble glucans (linear, branched, single helix, triple helix) and particulate glucans. From the viewpoint of structure and activity relationships, we found several characteristic features: i) hematopoietic response induced by the particulate glucan disappeared faster than that by the soluble glucans, ii) conformation of the glucans, single vs. triple helix, are relatively independent of the response, iii) linear glucan had a weaker response, and iv) there is a strong strain-dependency of the response. These results corresponded well with the fact that branched (1-->3)-beta-D-glucans, but not linear and not particulate, are often used as biological response modifiers for cancer patients." @default.
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- W2015375534 date "1997-01-01" @default.
- W2015375534 modified "2023-09-25" @default.
- W2015375534 title "Increases in Hematopoietic Responses Caused byβ-Glucans in Mice" @default.
- W2015375534 cites W2001566158 @default.
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- W2015375534 doi "https://doi.org/10.1271/bbb.61.1548" @default.
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