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• W2015380790 abstract "The potential of the low-frequency forced oscillation technique (FOT) to measure the response to inhaled salbutamol was studied in 13 infants with a history of recurrent wheeze and nine healthy infants. The input impedance of the respiratory system (Zrs) between 0.5 and 20 Hz was measured at a transrespiratory pressure of 20 cm H2O during a brief Hering-Breuer reflex-induced pause in breathing. Parameters representing the airway resistance (Raw) and inertance (Iaw), and a constant-phase tissue damping (G) and elastance (H) were estimated from the Zrs spectra. Lung function was measured before and after the administration of 500 μ g of salbutamol via a small-volume metal spacer. Six of these infants also received a placebo aerosol. A fall in Raw (13% for the entire group) occurred following treatment with salbutamol (p < 0.008) but not placebo. There was no significant difference in the response to salbutamol between the normal infants (7.65% ± 5.49%) and those with recurrent wheeze (17.58% ± 8.67%). On grouped data, the fall in G just failed to reach statistical significance (p = 0.05) after correcting the significance level for multiple tests. No significant change occurred in Iaw or H. We conclude that the low-frequency FOT is a suitable methodology for studying bronchodilator responsiveness in infants." @default.
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• W2015380790 date "1998-02-01" @default.
• W2015380790 modified "2023-10-16" @default.
• W2015380790 title "Using Low-frequency Oscillation to Detect Bronchodilator Responsiveness in Infants" @default.
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• W2015380790 doi "https://doi.org/10.1164/ajrccm.157.2.9703089" @default.
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