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• W2015383465 abstract "HomeHypertensionVol. 47, No. 1Obstructive Sleep Apnea in Overweight Subjects Free AccessResearch ArticlePDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessResearch ArticlePDF/EPUBObstructive Sleep Apnea in Overweight Subjects Miguel A. Arias, Ana M. Sánchez and Juan C. Fernández-Guerrero Alberto Alonso-Fernández and Francisco García-Río Miguel A. AriasMiguel A. Arias Department of Cardiology, Complejo Hospitalario de Jaén, Jaén, Spain Search for more papers by this author , Ana M. SánchezAna M. Sánchez Department of Cardiology, Complejo Hospitalario de Jaén, Jaén, Spain Search for more papers by this author and Juan C. Fernández-GuerreroJuan C. Fernández-Guerrero Department of Cardiology, Complejo Hospitalario de Jaén, Jaén, Spain Search for more papers by this author Alberto Alonso-FernándezAlberto Alonso-Fernández Department of Neumology, Hospital Universitario La Paz, Madrid, Spain Search for more papers by this author and Francisco García-RíoFrancisco García-Río Department of Neumology, Hospital Universitario La Paz, Madrid, Spain Search for more papers by this author Originally published28 Nov 2005https://doi.org/10.1161/01.HYP.0000196278.85101.4dHypertension. 2006;47:e1Other version(s) of this articleYou are viewing the most recent version of this article. Previous versions: November 28, 2005: Previous Version 1 To the Editor:In the excellent study by Thomas et al,1 a significant increased cardiovascular mortality rate was reported in obese individuals when that condition was associated with the presence of hypertension with or without other cardiovascular risk factors, such as hyperlipidemia or diabetes mellitus. As a result, the authors conclude that overweight should be considered as a major cardiovascular risk determinant. We would like to highlight the common association between obesity and obstructive sleep apnea (OSA), and why it is conceivable nowadays that OSA could be responsible, in part, for the cardiovascular mortality reported in obese subjects. Obesity is the main risk factor for developing OSA, and 40%2 to 90%3 of obese individuals are affected by OSA. Marin et al4 have recently reported a significantly higher incidence of fatal and nonfatal cardiovascular events in patients with untreated severe OSA as compared with untreated subjects with mild-moderate OSA, individuals correctly treated for OSA, and normal healthy subjects. Importantly, the increased risk of fatal and nonfatal cardiovascular events achieved in the group of untreated severe OSA patients was independent of other confounding factors such as body mass index or hypertension. Indeed, the association between OSA and systemic hypertension has also been well established.5 In view of the aforementioned data, it is our opinion that the possible presence of undiagnosed OSA should be investigated in every obese patient as another valuable measure to prevent the development of fatal and nonfatal cardiovascular events.1 Thomas F, Bean K, Pannier B, Oppert JM, Guize L, Benetos A. Cardiovascular mortality in overweight subjects: the key role of associated risk factors. Hypertension. 2005; 46: 654–659.LinkGoogle Scholar2 Vgontzas AN, Tan TL, Bixler EO, Martin LF, Shubert D, Kales A. Sleep apnea and sleep disruption in obese patients. Arch Intern Med. 1994; 154: 1705–1711.CrossrefMedlineGoogle Scholar3 Frey WC, Pilcher J. Obstructive sleep-related breathing disorders in patients evaluated for bariatric surgery. Obes Surg. 2003; 13: 676–683.CrossrefMedlineGoogle Scholar4 Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005; 365: 1046–1053.CrossrefMedlineGoogle Scholar5 Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003; 42: 1206–1252.LinkGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetails January 2006Vol 47, Issue 1 Advertisement Article InformationMetrics https://doi.org/10.1161/01.HYP.0000196278.85101.4dPMID: 16314493 Originally publishedNovember 28, 2005 PDF download Advertisement" @default.
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• W2015383465 title "Obstructive Sleep Apnea in Overweight Subjects" @default.
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