Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015389748> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2015389748 abstract "The trabecular meshwork (TM) is a smooth muscle-like tissue with contractile properties and by this mechanisms involved in the regulation of aqueous humor outflow. Isopropyl unoprostone (Rescula, Novartis Ophthalmics), a synthetic docosanoid, reduces intraocular pressure in glaucoma patients and normal subjects. In isolated TM strips, unoprostone reduces TM contractility in the presence of endothelin 1 (ET-1). However, the signal transduction pathway of unoprostone still remains unclear. Since L-type channel currents are known to influence the contractility of TM, we examined the effects of unoprostone and ET-1 on L-type channel currents of TM cells.The effects of unoprostone, ET-1 and the tyrosine kinase inhibitor herbimycin A on L-type channel currents of cultured human TM cells were investigated using the perforated patch configuration of the patch-clamp technique.Application of ET-1 had no effect on L-type channel currents. Unoprostone led to a dose-dependent reduction of control currents. The effect of unoprostone is independent of ET-1. After preincubation of cells with herbimycin A, unoprostone had no effect on the L-type channel current amplitude. Human TM cells preincubated with herbimycin A showed a reduced current density compared with control cells. Both substances, unoprostone and herbimycin A, increased the inactivation time constant of L-type channel currents.We conclude that unoprostone reduces the activity of L-type Ca2+ channels. This effect seems to be independent of ET-1. The signal transduction pathway seems to be mediated by tyrosine kinases." @default.
- W2015389748 created "2016-06-24" @default.
- W2015389748 creator A5003010605 @default.
- W2015389748 creator A5018694685 @default.
- W2015389748 creator A5020880864 @default.
- W2015389748 creator A5042244725 @default.
- W2015389748 creator A5050221844 @default.
- W2015389748 creator A5078625560 @default.
- W2015389748 creator A5090700813 @default.
- W2015389748 date "2005-01-01" @default.
- W2015389748 modified "2023-10-18" @default.
- W2015389748 title "Effects of Unoprostone and Endothelin 1 on L-Type Channel Currents in Human Trabecular Meshwork Cells" @default.
- W2015389748 cites W1561818412 @default.
- W2015389748 cites W1937680110 @default.
- W2015389748 cites W1973582529 @default.
- W2015389748 cites W1986276202 @default.
- W2015389748 cites W1989367993 @default.
- W2015389748 cites W2000180976 @default.
- W2015389748 cites W2002193991 @default.
- W2015389748 cites W2009667219 @default.
- W2015389748 cites W2040108714 @default.
- W2015389748 cites W2050280751 @default.
- W2015389748 cites W2052055142 @default.
- W2015389748 cites W2066899417 @default.
- W2015389748 cites W2079063592 @default.
- W2015389748 cites W2079202995 @default.
- W2015389748 cites W2082279160 @default.
- W2015389748 cites W2087255341 @default.
- W2015389748 cites W2122434993 @default.
- W2015389748 cites W2338721850 @default.
- W2015389748 doi "https://doi.org/10.1159/000087724" @default.
- W2015389748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16118512" @default.
- W2015389748 hasPublicationYear "2005" @default.
- W2015389748 type Work @default.
- W2015389748 sameAs 2015389748 @default.
- W2015389748 citedByCount "18" @default.
- W2015389748 countsByYear W20153897482012 @default.
- W2015389748 countsByYear W20153897482014 @default.
- W2015389748 countsByYear W20153897482016 @default.
- W2015389748 countsByYear W20153897482019 @default.
- W2015389748 countsByYear W20153897482020 @default.
- W2015389748 crossrefType "journal-article" @default.
- W2015389748 hasAuthorship W2015389748A5003010605 @default.
- W2015389748 hasAuthorship W2015389748A5018694685 @default.
- W2015389748 hasAuthorship W2015389748A5020880864 @default.
- W2015389748 hasAuthorship W2015389748A5042244725 @default.
- W2015389748 hasAuthorship W2015389748A5050221844 @default.
- W2015389748 hasAuthorship W2015389748A5078625560 @default.
- W2015389748 hasAuthorship W2015389748A5090700813 @default.
- W2015389748 hasConcept C105702510 @default.
- W2015389748 hasConcept C118487528 @default.
- W2015389748 hasConcept C126322002 @default.
- W2015389748 hasConcept C134018914 @default.
- W2015389748 hasConcept C144980905 @default.
- W2015389748 hasConcept C149601957 @default.
- W2015389748 hasConcept C170493617 @default.
- W2015389748 hasConcept C185592680 @default.
- W2015389748 hasConcept C2778527774 @default.
- W2015389748 hasConcept C2781121420 @default.
- W2015389748 hasConcept C71924100 @default.
- W2015389748 hasConcept C86803240 @default.
- W2015389748 hasConceptScore W2015389748C105702510 @default.
- W2015389748 hasConceptScore W2015389748C118487528 @default.
- W2015389748 hasConceptScore W2015389748C126322002 @default.
- W2015389748 hasConceptScore W2015389748C134018914 @default.
- W2015389748 hasConceptScore W2015389748C144980905 @default.
- W2015389748 hasConceptScore W2015389748C149601957 @default.
- W2015389748 hasConceptScore W2015389748C170493617 @default.
- W2015389748 hasConceptScore W2015389748C185592680 @default.
- W2015389748 hasConceptScore W2015389748C2778527774 @default.
- W2015389748 hasConceptScore W2015389748C2781121420 @default.
- W2015389748 hasConceptScore W2015389748C71924100 @default.
- W2015389748 hasConceptScore W2015389748C86803240 @default.
- W2015389748 hasLocation W20153897481 @default.
- W2015389748 hasLocation W20153897482 @default.
- W2015389748 hasOpenAccess W2015389748 @default.
- W2015389748 hasPrimaryLocation W20153897481 @default.
- W2015389748 hasRelatedWork W1888452903 @default.
- W2015389748 hasRelatedWork W2024739899 @default.
- W2015389748 hasRelatedWork W2155908309 @default.
- W2015389748 hasRelatedWork W2407208342 @default.
- W2015389748 hasRelatedWork W2910975531 @default.
- W2015389748 hasRelatedWork W2982327720 @default.
- W2015389748 hasRelatedWork W3181055448 @default.
- W2015389748 hasRelatedWork W3188404599 @default.
- W2015389748 hasRelatedWork W3200353195 @default.
- W2015389748 hasRelatedWork W4285595434 @default.
- W2015389748 isParatext "false" @default.
- W2015389748 isRetracted "false" @default.
- W2015389748 magId "2015389748" @default.
- W2015389748 workType "article" @default.