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- W2015390911 abstract "Both TGF/β2 and 5 have been described in the South African clawed frog <em>Xenopus laevis</em> and have been cloned from the tadpole-derived fibroblast cell line, XTC. Because TGF<em>β</em> has such a profound inhibitory effect on the mammalian immune system, this study was performed to determine whether TGF<em>β</em>: (a) has any <em>in vitro</em> effects on the growth of <em>Xenopus</em> lymphoblasts, and (b) is produced by mitogen-activated <em>Xenopus</em> lymphocytes.Following stimulation with mitogen or alloantigen, T lymphocytes from <em>Xenopus</em> secrete a T-cell growth factor (TCGF) that is functionally homologous to mammalian interleukin-2 (IL-2). Both recombinant human TGFβ1 and <em>Xenopus</em> TGF<em>β</em>5 inhibit TCGF-induced proliferation of <em>Xenopus</em> splenic blasts and this inhibition can be reversed with anti-pan TGF<em>β</em> antiserum. The Xenopus mitogen-induced saturated ammonium sulfate precipitated TCGF-containing supernatant (SAS TCGF SN) also contains latent TGF<em>β</em> as assayed on mink lung fibroblasts and <em>Xenopus</em> splenic blasts, and experiments utilizing anti-TGF<em>β</em> antiserum showed that only TGF<em>β</em>5 is present in this supernatant." @default.
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- W2015390911 date "1993-01-01" @default.
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- W2015390911 title "Transforming Growth Factor Beta (TGFβ) Is Produced by and Influences the Proliferative Response of Xenopus laevis Lymphocytes" @default.
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- W2015390911 doi "https://doi.org/10.1155/1993/63626" @default.
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