FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015392008> ?p ?o ?g. }

• W2015392008 endingPage "11869" @default.
• W2015392008 startingPage "11864" @default.
• W2015392008 abstract "The renal phenotype induced by loss-of-function mutations of inwardly rectifying potassium channel (Kir), Kcnj10 (Kir4.1), includes salt wasting, hypomagnesemia, metabolic alkalosis and hypokalemia. However, the mechanism by which Kir.4.1 mutations cause the tubulopathy is not completely understood. Here we demonstrate that Kcnj10 is a main contributor to the basolateral K conductance in the early distal convoluted tubule (DCT1) and determines the expression of the apical Na-Cl cotransporter (NCC) in the DCT. Immunostaining demonstrated Kcnj10 and Kcnj16 were expressed in the basolateral membrane of DCT, and patch-clamp studies detected a 40-pS K channel in the basolateral membrane of the DCT1 of p8/p10 wild-type Kcnj10(+/+) mice (WT). This 40-pS K channel is absent in homozygous Kcnj10(-/-) (knockout) mice. The disruption of Kcnj10 almost completely eliminated the basolateral K conductance and decreased the negativity of the cell membrane potential in DCT1. Moreover, the lack of Kcnj10 decreased the basolateral Cl conductance, inhibited the expression of Ste20-related proline-alanine-rich kinase and diminished the apical NCC expression in DCT. We conclude that Kcnj10 plays a dominant role in determining the basolateral K conductance and membrane potential of DCT1 and that the basolateral K channel activity in the DCT determines the apical NCC expression possibly through a Ste20-related proline-alanine-rich kinase-dependent mechanism." @default.
• W2015392008 created "2016-06-24" @default.
• W2015392008 creator A5000815865 @default.
• W2015392008 creator A5010068500 @default.
• W2015392008 creator A5021311035 @default.
• W2015392008 creator A5022287594 @default.
• W2015392008 creator A5027572620 @default.
• W2015392008 creator A5029871548 @default.
• W2015392008 creator A5032533121 @default.
• W2015392008 creator A5047765832 @default.
• W2015392008 creator A5048776453 @default.
• W2015392008 date "2014-07-28" @default.
• W2015392008 modified "2023-10-16" @default.
• W2015392008 title "KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1)" @default.
• W2015392008 cites W1964483243 @default.
• W2015392008 cites W1971877828 @default.
• W2015392008 cites W1982498018 @default.
• W2015392008 cites W1985793100 @default.
• W2015392008 cites W1986400814 @default.
• W2015392008 cites W1996108897 @default.
• W2015392008 cites W2000448320 @default.
• W2015392008 cites W2002951464 @default.
• W2015392008 cites W2017278666 @default.
• W2015392008 cites W2019251722 @default.
• W2015392008 cites W2032063322 @default.
• W2015392008 cites W2034675173 @default.
• W2015392008 cites W2039492547 @default.
• W2015392008 cites W2048332551 @default.
• W2015392008 cites W2048988573 @default.
• W2015392008 cites W2050875396 @default.
• W2015392008 cites W2052539926 @default.
• W2015392008 cites W2067549328 @default.
• W2015392008 cites W2069917528 @default.
• W2015392008 cites W2079163382 @default.
• W2015392008 cites W2093986108 @default.
• W2015392008 cites W2097799706 @default.
• W2015392008 cites W2106365130 @default.
• W2015392008 cites W2107609623 @default.
• W2015392008 cites W2108421346 @default.
• W2015392008 cites W2116883656 @default.
• W2015392008 cites W2125003736 @default.
• W2015392008 cites W2130632820 @default.
• W2015392008 cites W2132278911 @default.
• W2015392008 cites W2135394966 @default.
• W2015392008 cites W2138585774 @default.
• W2015392008 cites W2142315301 @default.
• W2015392008 cites W2145443644 @default.
• W2015392008 cites W2161168230 @default.
• W2015392008 cites W2161276475 @default.
• W2015392008 cites W2162430687 @default.
• W2015392008 cites W2162889119 @default.
• W2015392008 cites W2163261467 @default.
• W2015392008 cites W2164112784 @default.
• W2015392008 cites W2164584173 @default.
• W2015392008 cites W2170467789 @default.
• W2015392008 cites W2253773006 @default.
• W2015392008 cites W2413282643 @default.
• W2015392008 doi "https://doi.org/10.1073/pnas.1411705111" @default.
• W2015392008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4136599" @default.
• W2015392008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25071208" @default.
• W2015392008 hasPublicationYear "2014" @default.
• W2015392008 type Work @default.
• W2015392008 sameAs 2015392008 @default.
• W2015392008 citedByCount "132" @default.
• W2015392008 countsByYear W20153920082013 @default.
• W2015392008 countsByYear W20153920082015 @default.
• W2015392008 countsByYear W20153920082016 @default.
• W2015392008 countsByYear W20153920082017 @default.
• W2015392008 countsByYear W20153920082018 @default.
• W2015392008 countsByYear W20153920082019 @default.
• W2015392008 countsByYear W20153920082020 @default.
• W2015392008 countsByYear W20153920082021 @default.
• W2015392008 countsByYear W20153920082022 @default.
• W2015392008 countsByYear W20153920082023 @default.
• W2015392008 crossrefType "journal-article" @default.
• W2015392008 hasAuthorship W2015392008A5000815865 @default.
• W2015392008 hasAuthorship W2015392008A5010068500 @default.
• W2015392008 hasAuthorship W2015392008A5021311035 @default.
• W2015392008 hasAuthorship W2015392008A5022287594 @default.
• W2015392008 hasAuthorship W2015392008A5027572620 @default.
• W2015392008 hasAuthorship W2015392008A5029871548 @default.
• W2015392008 hasAuthorship W2015392008A5032533121 @default.
• W2015392008 hasAuthorship W2015392008A5047765832 @default.
• W2015392008 hasAuthorship W2015392008A5048776453 @default.
• W2015392008 hasBestOaLocation W20153920081 @default.
• W2015392008 hasConcept C104317684 @default.
• W2015392008 hasConcept C120405084 @default.
• W2015392008 hasConcept C12554922 @default.
• W2015392008 hasConcept C126322002 @default.
• W2015392008 hasConcept C134018914 @default.
• W2015392008 hasConcept C149011108 @default.
• W2015392008 hasConcept C1491633281 @default.
• W2015392008 hasConcept C178790620 @default.
• W2015392008 hasConcept C181911157 @default.
• W2015392008 hasConcept C185592680 @default.
• W2015392008 hasConcept C188053792 @default.
• W2015392008 hasConcept C204232928 @default.
• W2015392008 hasConcept C2776777027 @default.

• next