FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015392176> ?p ?o ?g. }

• W2015392176 endingPage "355" @default.
• W2015392176 startingPage "346" @default.
• W2015392176 abstract "Cellular debris, an indicator of cell death, appears in limb buds of gestational day 12 rabbit embryos 4 hr after either a subcutaneous injection of hydroxyurea to pregnant rabbits or an injection of hydroxyurea into the exocoelomic cavities of the embryos. This episode of early cell death appears to be central to the teratogenic action of hydroxyurea. Several chemicals that are structurally related to hydroxyurea, and that possess a terminal hydroxylamine moiety (-NHOH), also produce limb abnormalities.To investigate whether the hydroxylamine moiety is responsible for early cell death and, therefore, is likely to be associated with teratogenesis, five structurally related hydroxylamine-bearing chemicals (hydroxylamine hydrochloride, N-methylhydroxylamine hydrochloride, hydroxyurea, acetohydroxamic acid, and hydroxyurethane) were administered at equimolar doses to rabbits either by subcutaneous (8.55 mmol/kg) or intracoelomic (2.66 micromol/embryo) injection on gestational day 12. Five additional chemicals, structurally similar to the hydroxylamine-bearing compounds, but possessing a terminal amino group (-NH(2)) (ammonium hydroxide, methylamine, urea, acetamide, and urethane), were tested at equimolar or higher doses by an identical protocol. In a subsequent experiment, the antioxidant propyl gallate (3.0 mmol/kg or 1.30 micromol/embryo) was co-administered with the hydroxylamine-bearing compounds to determine its effect on early cell death. Embryos were harvested 4 or 8 hr after treatment and analyzed by light microscopy.Cellular debris was obvious in forelimb buds from embryos treated with the hydroxylamine-bearing compounds; however, none of the amino compounds produced an early episode of embryonic cell death. In all cases, the antioxidant propyl gallate prevented or delayed the early episode of cell death observed after treatment with the hydroxylamine-bearing compounds.These results are consistent with the concept that the rapidly occurring embryonic cytotoxicity induced by hydroxylamine-bearing compounds involves a free radical mechanism that requires the presence of a terminal hydroxylamine group for initiation." @default.
• W2015392176 created "2016-06-24" @default.
• W2015392176 creator A5014917015 @default.
• W2015392176 creator A5029493372 @default.
• W2015392176 creator A5037991714 @default.
• W2015392176 creator A5066183536 @default.
• W2015392176 date "2000-01-01" @default.
• W2015392176 modified "2023-09-23" @default.
• W2015392176 title "Hydroxylamine moiety of developmental toxicants is associated with early cell death: A structure-activity analysis" @default.
• W2015392176 cites W1511223524 @default.
• W2015392176 cites W1966377689 @default.
• W2015392176 cites W1970620745 @default.
• W2015392176 cites W1971141682 @default.
• W2015392176 cites W1974515830 @default.
• W2015392176 cites W1974923698 @default.
• W2015392176 cites W1985289624 @default.
• W2015392176 cites W1992542423 @default.
• W2015392176 cites W2005943986 @default.
• W2015392176 cites W2009078954 @default.
• W2015392176 cites W2012996381 @default.
• W2015392176 cites W2016350172 @default.
• W2015392176 cites W2026205498 @default.
• W2015392176 cites W2028648417 @default.
• W2015392176 cites W2034154770 @default.
• W2015392176 cites W2036228850 @default.
• W2015392176 cites W2043742352 @default.
• W2015392176 cites W2048658699 @default.
• W2015392176 cites W2054911568 @default.
• W2015392176 cites W2057547383 @default.
• W2015392176 cites W2061400832 @default.
• W2015392176 cites W2065858774 @default.
• W2015392176 cites W2066352959 @default.
• W2015392176 cites W2067812785 @default.
• W2015392176 cites W2070560929 @default.
• W2015392176 cites W2072089033 @default.
• W2015392176 cites W2073995791 @default.
• W2015392176 cites W2076847563 @default.
• W2015392176 cites W2081718813 @default.
• W2015392176 cites W2083741109 @default.
• W2015392176 cites W2084181354 @default.
• W2015392176 cites W2092937035 @default.
• W2015392176 cites W2093695182 @default.
• W2015392176 cites W2094586853 @default.
• W2015392176 cites W2111806753 @default.
• W2015392176 cites W2138936818 @default.
• W2015392176 cites W2159268375 @default.
• W2015392176 doi "https://doi.org/10.1002/1096-9926(200011)62:5<346::aid-tera9>3.0.co;2-1" @default.
• W2015392176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11029153" @default.
• W2015392176 hasPublicationYear "2000" @default.
• W2015392176 type Work @default.
• W2015392176 sameAs 2015392176 @default.
• W2015392176 citedByCount "13" @default.
• W2015392176 countsByYear W20153921762013 @default.
• W2015392176 countsByYear W20153921762014 @default.
• W2015392176 countsByYear W20153921762016 @default.
• W2015392176 countsByYear W20153921762018 @default.
• W2015392176 crossrefType "journal-article" @default.
• W2015392176 hasAuthorship W2015392176A5014917015 @default.
• W2015392176 hasAuthorship W2015392176A5029493372 @default.
• W2015392176 hasAuthorship W2015392176A5037991714 @default.
• W2015392176 hasAuthorship W2015392176A5066183536 @default.
• W2015392176 hasConcept C16685009 @default.
• W2015392176 hasConcept C185592680 @default.
• W2015392176 hasConcept C190283241 @default.
• W2015392176 hasConcept C2775999725 @default.
• W2015392176 hasConcept C31573885 @default.
• W2015392176 hasConcept C55493867 @default.
• W2015392176 hasConcept C71924100 @default.
• W2015392176 hasConcept C86803240 @default.
• W2015392176 hasConcept C98274493 @default.
• W2015392176 hasConceptScore W2015392176C16685009 @default.
• W2015392176 hasConceptScore W2015392176C185592680 @default.
• W2015392176 hasConceptScore W2015392176C190283241 @default.
• W2015392176 hasConceptScore W2015392176C2775999725 @default.
• W2015392176 hasConceptScore W2015392176C31573885 @default.
• W2015392176 hasConceptScore W2015392176C55493867 @default.
• W2015392176 hasConceptScore W2015392176C71924100 @default.
• W2015392176 hasConceptScore W2015392176C86803240 @default.
• W2015392176 hasConceptScore W2015392176C98274493 @default.
• W2015392176 hasIssue "5" @default.
• W2015392176 hasLocation W20153921761 @default.
• W2015392176 hasLocation W20153921762 @default.
• W2015392176 hasOpenAccess W2015392176 @default.
• W2015392176 hasPrimaryLocation W20153921761 @default.
• W2015392176 hasRelatedWork W1993074682 @default.
• W2015392176 hasRelatedWork W2008446359 @default.
• W2015392176 hasRelatedWork W2053825085 @default.
• W2015392176 hasRelatedWork W2074351572 @default.
• W2015392176 hasRelatedWork W2325146479 @default.
• W2015392176 hasRelatedWork W2606148012 @default.
• W2015392176 hasRelatedWork W2880402987 @default.
• W2015392176 hasRelatedWork W2949077129 @default.
• W2015392176 hasRelatedWork W2949676243 @default.
• W2015392176 hasRelatedWork W2951854811 @default.
• W2015392176 hasVolume "62" @default.
• W2015392176 isParatext "false" @default.
• W2015392176 isRetracted "false" @default.
• W2015392176 magId "2015392176" @default.

• next