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- W2015392322 abstract "Post-infective fatigue syndrome (PIFS) is a prevalent and disabling condition following directly from acute viral infections. We have previously documented strong relationships between the inflammatory response and symptom severity during the acute illness. Here, we report detailed longitudinal analyses of the potential importance of cytokine abnormalities in the pathogenesis of PIFS. Additionally, we explored a role for disordered autonomic signalling in failing to recover from infection. Longitudinal analyses utilized peripheral blood and clinical data collected over 12 months in a large prospective cohort study (n = 515). Ex vivo production of eight cytokines by peripheral blood mononuclear cells was analysed (BioPlex) in 22 cases with PIFS and 42 controls who recovered uneventfully. Autonomic activity was assessed via electrocardiogram in several patient samples and matched controls to explore a role for vagus nerve activity [inferred from heart rate variability (HRV)] in facilitating recovery from infection; and to characterize autonomic functioning in PIFS. PIFS was not related to abnormal cytokine production at any time, across all culture conditions (all p > 0.05). In patients with acute infections, increased HRV was significantly associated with lower levels of C-reactive protein (p = 0.002) and shorter illness duration (p = 0.005). PIFS status was consistently linked to low HRV. Taken together, these findings suggest that events that occur early during infection and linked to disordered neural signalling are likely to be critical to understanding the pathogenesis of PIFS." @default.
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- W2015392322 date "2014-09-01" @default.
- W2015392322 modified "2023-10-17" @default.
- W2015392322 title "42. Post-infective fatigue syndrome: Immunological and autonomic findings" @default.
- W2015392322 doi "https://doi.org/10.1016/j.bbi.2014.06.062" @default.
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