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- W2015393070 abstract "OBJECTIVE: Endometriosis is a condition characterized by the presence of endometrial tissue (stroma & glands) outside the uterus causing dysmenorrhea, dyspareunia and often infertility. The causes of endometriosis-associated infertility remain unknown, but previous studies have identified altered gene expression profiles which may result in endometrial dysfunctions leading to implantation failure. Lysyl oxidases (LOXs) are copper-dependent enzymes with roles in transcriptional regulation, cell adhesion, invasion, and extracellular matrix stability. These enzymes have been shown to be upregulated in endometriotic tissues in both humans and animal models. The purpose of this study is to determine whether levels of expression of LOX in endometrium differ among patients with endometriosis and fertile women (controls). DESIGN: A case-control study was conducted to determine the level of expression of LOX in formalin-fixed paraffin-embedded (FFPE) endometrial biopsies obtained from women with endometriosis-associated infertility and fertile women. MATERIALS AND METHODS: Endometrial biopsies were obtained during the window of implantation (WOI) in collaboration with infertility clinics in Puerto Rico. Immunohistochemistry (IHC) analysis was conducted following standard methods using a polyclonal anti-human LOX antibody. Immunostaining was scored semiquantitatively by three independent observers, using the 1-3 score system (1 = weak, 2 = moderate, 3 = strong). RESULTS: We observed increased expression of LOX in epithelial cells of women with endometriosis-associated infertility versus fertile women. Meanwhile, a lower expression of LOX was seen in the stromal compartment in patients with endometriosis compared to their fertile counterparts. CONCLUSIONS: Successful blastocyst implantation requires attachment to the uterine luminal epithelium and synthesis of extracellular matrix components associated with decidualization of endometrial stroma. Therefore, aberrant expression of LOX in the endometrium of patients with endometriosis may cause defects in adhesion and decidualization leading to infertility." @default.
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- W2015393070 date "2008-09-01" @default.
- W2015393070 modified "2023-09-30" @default.
- W2015393070 title "Lysyl oxidase is differentially expressed in women with endometriosis-associated infertility compared to fertile women" @default.
- W2015393070 doi "https://doi.org/10.1016/j.fertnstert.2008.07.257" @default.
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