Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015395844> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2015395844 endingPage "180" @default.
- W2015395844 startingPage "171" @default.
- W2015395844 abstract "Experiments were perfomed in rats to elucidate the role of central 5-HT and catecholamines in the mediation of the antinociceptive effects of d-amphetamine, d-p-chloroamphetamine, morphine and aminopyrine. The method of Randall and Selitto (1957) was used for determining the antinociceptive effect. The antinociceptive effects of both amphetamines and of morphine was antagonized by pretreatment with p-chlorophenylalanine and restored by 5-HTP. The 5-HT antagonist, cyproheptadine also exerted a strong antagonism. Central turnover of 5-HT was enhanced at the time of the antinociceptive effects of morphine and p-chloroamphetamine. α-Methyltyrosine abolished the antinociceptive drug effects in very low doses, but disulfiram did not. Of the catecholamine antagonistic drugs, haloperidol proved to be effective in doses which must be considered as purely dopamine antagonistic. Therefore, the results point to a participation of 5-HT and dopamine in the central mediation of antinociceptive drug effects. Of these amines, the former seems to be a major significance for morphine and p-chloroamphetamine, the latter for amphetamine. In the case of aminopyrine, only pretreatment with p-chlorophenylalanine resulted in a somewhat doubtful antagonism." @default.
- W2015395844 created "2016-06-24" @default.
- W2015395844 creator A5009452576 @default.
- W2015395844 creator A5015227895 @default.
- W2015395844 date "1972-11-01" @default.
- W2015395844 modified "2023-10-14" @default.
- W2015395844 title "Central monoamines and antinociceptive drug action" @default.
- W2015395844 cites W1963536104 @default.
- W2015395844 cites W1983789165 @default.
- W2015395844 cites W1990784490 @default.
- W2015395844 cites W1999286993 @default.
- W2015395844 cites W2011466337 @default.
- W2015395844 cites W2013718093 @default.
- W2015395844 cites W2022044242 @default.
- W2015395844 cites W2031478752 @default.
- W2015395844 cites W2055187003 @default.
- W2015395844 cites W2058720685 @default.
- W2015395844 cites W2059423328 @default.
- W2015395844 cites W2059512619 @default.
- W2015395844 cites W2063896365 @default.
- W2015395844 cites W2073066407 @default.
- W2015395844 cites W2165673864 @default.
- W2015395844 cites W4245469420 @default.
- W2015395844 doi "https://doi.org/10.1016/0014-2999(72)90146-x" @default.
- W2015395844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4265524" @default.
- W2015395844 hasPublicationYear "1972" @default.
- W2015395844 type Work @default.
- W2015395844 sameAs 2015395844 @default.
- W2015395844 citedByCount "142" @default.
- W2015395844 countsByYear W20153958442017 @default.
- W2015395844 countsByYear W20153958442018 @default.
- W2015395844 crossrefType "journal-article" @default.
- W2015395844 hasAuthorship W2015395844A5009452576 @default.
- W2015395844 hasAuthorship W2015395844A5015227895 @default.
- W2015395844 hasConcept C126322002 @default.
- W2015395844 hasConcept C15490471 @default.
- W2015395844 hasConcept C170493617 @default.
- W2015395844 hasConcept C185592680 @default.
- W2015395844 hasConcept C187714386 @default.
- W2015395844 hasConcept C2775864247 @default.
- W2015395844 hasConcept C2777383412 @default.
- W2015395844 hasConcept C2777389121 @default.
- W2015395844 hasConcept C2778206117 @default.
- W2015395844 hasConcept C2780948584 @default.
- W2015395844 hasConcept C2910298800 @default.
- W2015395844 hasConcept C37000724 @default.
- W2015395844 hasConcept C513476851 @default.
- W2015395844 hasConcept C55493867 @default.
- W2015395844 hasConcept C71924100 @default.
- W2015395844 hasConcept C98274493 @default.
- W2015395844 hasConceptScore W2015395844C126322002 @default.
- W2015395844 hasConceptScore W2015395844C15490471 @default.
- W2015395844 hasConceptScore W2015395844C170493617 @default.
- W2015395844 hasConceptScore W2015395844C185592680 @default.
- W2015395844 hasConceptScore W2015395844C187714386 @default.
- W2015395844 hasConceptScore W2015395844C2775864247 @default.
- W2015395844 hasConceptScore W2015395844C2777383412 @default.
- W2015395844 hasConceptScore W2015395844C2777389121 @default.
- W2015395844 hasConceptScore W2015395844C2778206117 @default.
- W2015395844 hasConceptScore W2015395844C2780948584 @default.
- W2015395844 hasConceptScore W2015395844C2910298800 @default.
- W2015395844 hasConceptScore W2015395844C37000724 @default.
- W2015395844 hasConceptScore W2015395844C513476851 @default.
- W2015395844 hasConceptScore W2015395844C55493867 @default.
- W2015395844 hasConceptScore W2015395844C71924100 @default.
- W2015395844 hasConceptScore W2015395844C98274493 @default.
- W2015395844 hasIssue "2" @default.
- W2015395844 hasLocation W20153958441 @default.
- W2015395844 hasLocation W20153958442 @default.
- W2015395844 hasOpenAccess W2015395844 @default.
- W2015395844 hasPrimaryLocation W20153958441 @default.
- W2015395844 hasRelatedWork W1972906791 @default.
- W2015395844 hasRelatedWork W2010121394 @default.
- W2015395844 hasRelatedWork W2091289850 @default.
- W2015395844 hasRelatedWork W2102693660 @default.
- W2015395844 hasRelatedWork W2141778251 @default.
- W2015395844 hasRelatedWork W2158878790 @default.
- W2015395844 hasRelatedWork W2414859212 @default.
- W2015395844 hasRelatedWork W2418507501 @default.
- W2015395844 hasRelatedWork W3014125577 @default.
- W2015395844 hasRelatedWork W3157961938 @default.
- W2015395844 hasVolume "20" @default.
- W2015395844 isParatext "false" @default.
- W2015395844 isRetracted "false" @default.
- W2015395844 magId "2015395844" @default.
- W2015395844 workType "article" @default.