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• W2015403895 abstract "In absence of their natural ligand, 11-<i>cis</i>-retinal, cone opsin G-protein-coupled receptors fail to traffic normally, a condition associated with photoreceptor degeneration and blindness. We created a mouse with a point mutation (F81Y) in cone S-opsin. As expected, cones with this knock-in mutation respond to light with maximal sensitivity red-shifted from 360 to 420 nm, consistent with an altered interaction between the apoprotein and ligand, 11-<i>cis</i>-retinal. However, cones expressing F81Y S-opsin showed an ∼3-fold reduced absolute sensitivity that was associated with a corresponding reduction in S-opsin protein expression. The reduced S-opsin expression did not arise from decreased S-opsin mRNA or cone degeneration, but rather from enhanced endoplasmic reticulum (ER)-associated degradation of the nascent protein. Exogenously increased 11-<i>cis</i>-retinal restored F81Y S-opsin protein expression to normal levels, suggesting that ligand binding in the ER facilitates proper folding. Immunohistochemistry and electron microscopy of normal retinas showed that Mueller cells, which synthesize a precursor of 11-<i>cis</i>-retinal, are closely adjoined to the cone ER, so they could deliver the ligand to the site of opsin synthesis. Together, these results suggest that the binding of 11-<i>cis</i>-retinal in the ER is important for normal folding during cone opsin biosynthesis." @default.
• W2015403895 created "2016-06-24" @default.
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• W2015403895 date "2012-06-06" @default.
• W2015403895 modified "2023-09-25" @default.
• W2015403895 title "An S-Opsin Knock-In Mouse (F81Y) Reveals a Role for the Native Ligand 11-cis-Retinal in Cone Opsin Biosynthesis" @default.
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• W2015403895 cites W1992950258 @default.
• W2015403895 cites W1993277813 @default.
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• W2015403895 doi "https://doi.org/10.1523/jneurosci.0131-12.2012" @default.
• W2015403895 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3381355" @default.
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• W2015403895 hasPublicationYear "2012" @default.
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