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• W2015405770 abstract "<h3>Objective</h3> To evaluate the efficacy and safety of proton beam therapy for complicatedcircumscribed choroidal hemangiomas. <h3>Methods</h3> The study was a retrospective nonrandomized investigation. Seventeenconsecutive patients, referred to the Institut Gustave-Roussy, Villejuif,France, for circumscribed choroidal hemangioma associated with serous retinaldetachment were studied. Each eye received a total dose of 20 cobalt grayequivalents (CGEs) delivered in 15-second fractions of 5 CGEs over 4 days.Functional tests included the initial and final best-corrected visual acuity,slitlamp examination, intraocular pressure, fundus examination, fluoresceinangiography, and indocyanine green angiography. Tumor thickness was determinedon B-scan ultrasonography. <h3>Results</h3> The macula was involved in 7 eyes and the lesion was juxtapapillaryin 2 eyes. The mean (SD) tumor thickness was 3.06 (9.0) mm. The mean initialtumor diameter was 6.82 mm (range, 3.2-12.1 mm). The right eye was involvedin 7 cases and the left eye in 10 cases. The mean (SD) follow-up period was52 (58) months (range, 36-90 months). Retinal reattachment was obtained inall cases after a mean period of 2 months (range, 1-12 months; median, 1 month).Tumor regression was obtained in all cases. One recurrence occurred 1 yearafter the initial treatment in an undertreated area. After re-treatment, however,resolution of the retinal detachment occurred, and flattening of the choroidallesion was obtained. Final visual acuity improved to 2 Snellen lines or morein 16 eyes (94%), was stable in 1 eye, and attained 20/40 or more in 12 eyes(70.6%). No radiation therapy complications occurred during follow-up. <h3>Conclusions</h3> Proton beam therapy for choroidal hemangiomas seems to be an effectiveand safe alternative option. A total dose of 20 CGEs delivered in 4 daily15-second fractions of 5 CGEs seems adequate for local control of both thetumor and serous retinal detachment." @default.
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• W2015405770 date "2004-10-01" @default.
• W2015405770 modified "2023-10-18" @default.
• W2015405770 title "Low-Dose Proton Beam Therapy for Circumscribed Choroidal Hemangiomas" @default.
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• W2015405770 doi "https://doi.org/10.1001/archopht.122.10.1471" @default.
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