Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015407742> ?p ?o ?g. }
- W2015407742 endingPage "887" @default.
- W2015407742 startingPage "875" @default.
- W2015407742 abstract "Importance of the field: Platinum-based chemotherapy is considered the standard-of-care first-line therapy for metastatic bladder cancer. Despite the initial high response rate, the vast majority of patients eventually progress and succumb to their disease, urging the need for development of novel therapies.Areas covered in this review: This article discusses the main signaling pathways implicated in the pathogenesis of bladder carcinomas, reviews recently completed and ongoing clinical trials, and anticipates the future direction of molecularly targeted agents.What the reader will gain: This manuscript presents the current status of conventional chemotherapy in advanced bladder cancer, and provides a comprehensive review of molecular targeted agents currently in clinical development for this disease.Take home message: Improved understanding of the biology of urothelial carcinogenesis has paved the way for the development of novel molecularly targeted therapies, several of which are currently tested in clinical trials. In this regard, VEGF and EGFR pathways are emerging as important therapeutic targets for metastatic bladder cancer, either alone or in combination with conventional chemotherapeutics. Other therapies, including aurora kinase inhibitors, endothelin receptor antagonists, RAS/MAPK pathway inhibitors and novel immunologic strategies, may also prove helpful in the treatment of this disease." @default.
- W2015407742 created "2016-06-24" @default.
- W2015407742 creator A5020683373 @default.
- W2015407742 creator A5036478814 @default.
- W2015407742 creator A5052517445 @default.
- W2015407742 creator A5060046727 @default.
- W2015407742 creator A5071780710 @default.
- W2015407742 creator A5076246054 @default.
- W2015407742 creator A5077783091 @default.
- W2015407742 creator A5084550691 @default.
- W2015407742 date "2010-06-08" @default.
- W2015407742 modified "2023-09-23" @default.
- W2015407742 title "Systemic therapy of metastatic bladder cancer in the molecular era: current status and future promise" @default.
- W2015407742 cites W1554602088 @default.
- W2015407742 cites W1563019250 @default.
- W2015407742 cites W1573363574 @default.
- W2015407742 cites W1588429113 @default.
- W2015407742 cites W1612261942 @default.
- W2015407742 cites W1657157395 @default.
- W2015407742 cites W1820014750 @default.
- W2015407742 cites W1857682357 @default.
- W2015407742 cites W1893740135 @default.
- W2015407742 cites W1941332786 @default.
- W2015407742 cites W1964169184 @default.
- W2015407742 cites W1967384609 @default.
- W2015407742 cites W1976630291 @default.
- W2015407742 cites W1977305815 @default.
- W2015407742 cites W1983508961 @default.
- W2015407742 cites W1984429541 @default.
- W2015407742 cites W1984692133 @default.
- W2015407742 cites W1985014438 @default.
- W2015407742 cites W1986266121 @default.
- W2015407742 cites W1991541715 @default.
- W2015407742 cites W1995328364 @default.
- W2015407742 cites W2002920392 @default.
- W2015407742 cites W2012545692 @default.
- W2015407742 cites W2021813410 @default.
- W2015407742 cites W2033248824 @default.
- W2015407742 cites W2037139254 @default.
- W2015407742 cites W2039609330 @default.
- W2015407742 cites W2040596213 @default.
- W2015407742 cites W2042906712 @default.
- W2015407742 cites W2049043995 @default.
- W2015407742 cites W2049662137 @default.
- W2015407742 cites W2054045494 @default.
- W2015407742 cites W2063170049 @default.
- W2015407742 cites W2064808880 @default.
- W2015407742 cites W2066984265 @default.
- W2015407742 cites W2067114310 @default.
- W2015407742 cites W2075793247 @default.
- W2015407742 cites W2078811155 @default.
- W2015407742 cites W2079384315 @default.
- W2015407742 cites W2082205186 @default.
- W2015407742 cites W2082827117 @default.
- W2015407742 cites W2088179569 @default.
- W2015407742 cites W2093043664 @default.
- W2015407742 cites W2095771928 @default.
- W2015407742 cites W2100127605 @default.
- W2015407742 cites W2101562875 @default.
- W2015407742 cites W2101995865 @default.
- W2015407742 cites W2102116016 @default.
- W2015407742 cites W2102917490 @default.
- W2015407742 cites W2103257412 @default.
- W2015407742 cites W2104845282 @default.
- W2015407742 cites W2107137908 @default.
- W2015407742 cites W2111060860 @default.
- W2015407742 cites W2113156769 @default.
- W2015407742 cites W2114371641 @default.
- W2015407742 cites W2114699723 @default.
- W2015407742 cites W2116813877 @default.
- W2015407742 cites W2123086444 @default.
- W2015407742 cites W2124254102 @default.
- W2015407742 cites W2126592740 @default.
- W2015407742 cites W2133330931 @default.
- W2015407742 cites W2136968982 @default.
- W2015407742 cites W2137429755 @default.
- W2015407742 cites W2140858291 @default.
- W2015407742 cites W2142720921 @default.
- W2015407742 cites W2143807312 @default.
- W2015407742 cites W2147609992 @default.
- W2015407742 cites W2148936981 @default.
- W2015407742 cites W2152334952 @default.
- W2015407742 cites W2159609881 @default.
- W2015407742 cites W2161204067 @default.
- W2015407742 cites W2280309969 @default.
- W2015407742 cites W2324677651 @default.
- W2015407742 cites W2402166800 @default.
- W2015407742 cites W2966607965 @default.
- W2015407742 cites W4233300983 @default.
- W2015407742 cites W4237933334 @default.
- W2015407742 cites W2604377350 @default.
- W2015407742 doi "https://doi.org/10.1517/13543784.2010.496450" @default.
- W2015407742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20528482" @default.
- W2015407742 hasPublicationYear "2010" @default.
- W2015407742 type Work @default.
- W2015407742 sameAs 2015407742 @default.
- W2015407742 citedByCount "22" @default.
- W2015407742 countsByYear W20154077422012 @default.