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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015409533> ?p ?o ?g. }

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• W2015409533 abstract "One of the most important factors in the production of cartilage is transforming growth factor β1 (TGF-β1). To obtain sustained release of TGF-β1, a cell-mediated gene therapy technique was introduced. We infected chondrocytes with a retroviral vector carrying the TGF-β1 gene. The single clone derivative showed sustained TGF-β1 secretion. It also showed constitutive type II collagen expression. Whereas the TGF-β1 protein itself is unable to induce formation of cartilage in vivo, human chondrocytes engineered to express a retroviral vector encoding TGF-β1 showed cartilage formation in vivo when cells were injected into nude mice intradermally. These data suggest that cell-mediated gene therapy using TGF-β1 as a transgene would be a promising treatment for osteoarthritis." @default.
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• W2015409533 date "2005-01-01" @default.
• W2015409533 modified "2023-09-25" @default.
• W2015409533 title "Continuous Transforming Growth Factor β₁Secretion by Cell-Mediated Gene Therapy Maintains Chondrocyte Redifferentiation" @default.
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• W2015409533 doi "https://doi.org/10.1089/ten.2005.11.310" @default.
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