FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015410192> ?p ?o ?g. }

• W2015410192 endingPage "e28666" @default.
• W2015410192 startingPage "e28666" @default.
• W2015410192 abstract "Normal aging is associated with impairments in cognition, especially learning and memory. However, major individual differences are known to exist. Using the classical Morris Water Maze (MWM) task, we discriminated a population of 24-months old Long Evans aged rats in two groups--memory-impaired (AI) and memory-unimpaired (AU) in comparison with 6-months old adult animals. AI rats presented deficits in learning, reverse memory and retention. At the molecular level, an increase in metabotropic glutamate receptors 5 (mGluR5) was observed in post-synaptic densities (PSD) in the hippocampus of AU rats after training. Scaffolding Homer 1b/c proteins binding to group 1 mGluR facilitate coupling with its signaling effectors while Homer 1a reduces it. Both Homer 1a and 1b/c levels were up-regulated in the hippocampus PSD of AU animals following MWM task. Using immunohistochemistry we further demonstrated that mGluR5 as well as Homer 1b/c stainings were enhanced in the CA1 hippocampus sub-field of AU animals. In fact mGluR5 and Homer 1 isoforms were more abundant and co-localized in the hippocampal dendrites in AU rats. However, the ratio of Homer 1a/Homer 1b/c bound to mGluR5 in the PSD was four times lower for AU animals compared to AI rats. Consequently, AU animals presented higher PKCγ, ERK, p70S6K, mTOR and CREB activation. Finally the expression of immediate early gene Arc/Arg3.1 was shown to be higher in AU rats in accordance with its role in spatial memory consolidation. On the basis of these results, a model of successful cognitive aging with a critical role for mGluR5, Homer 1 proteins and downstream signalling pathways is proposed here." @default.
• W2015410192 created "2016-06-24" @default.
• W2015410192 creator A5055183128 @default.
• W2015410192 creator A5062929009 @default.
• W2015410192 date "2012-01-06" @default.
• W2015410192 modified "2023-09-27" @default.
• W2015410192 title "Successful Cognitive Aging in Rats: A Role for mGluR5 Glutamate Receptors, Homer 1 Proteins and Downstream Signaling Pathways" @default.
• W2015410192 cites W1763958744 @default.
• W2015410192 cites W1780394705 @default.
• W2015410192 cites W1794950817 @default.
• W2015410192 cites W1821495885 @default.
• W2015410192 cites W1855068507 @default.
• W2015410192 cites W1964790038 @default.
• W2015410192 cites W1966225158 @default.
• W2015410192 cites W1966418219 @default.
• W2015410192 cites W1968883861 @default.
• W2015410192 cites W1969171499 @default.
• W2015410192 cites W1970041992 @default.
• W2015410192 cites W1972974216 @default.
• W2015410192 cites W1973417580 @default.
• W2015410192 cites W1981114447 @default.
• W2015410192 cites W1983949152 @default.
• W2015410192 cites W1984287060 @default.
• W2015410192 cites W1992377744 @default.
• W2015410192 cites W1995680954 @default.
• W2015410192 cites W1999548133 @default.
• W2015410192 cites W1999565389 @default.
• W2015410192 cites W2003655335 @default.
• W2015410192 cites W2005016731 @default.
• W2015410192 cites W2016498171 @default.
• W2015410192 cites W2018157246 @default.
• W2015410192 cites W2018177327 @default.
• W2015410192 cites W2018876606 @default.
• W2015410192 cites W2019372876 @default.
• W2015410192 cites W2020976619 @default.
• W2015410192 cites W2024758252 @default.
• W2015410192 cites W2030214963 @default.
• W2015410192 cites W2031381106 @default.
• W2015410192 cites W2031994595 @default.
• W2015410192 cites W2037456771 @default.
• W2015410192 cites W2038826547 @default.
• W2015410192 cites W2042651745 @default.
• W2015410192 cites W2046316453 @default.
• W2015410192 cites W2046390430 @default.
• W2015410192 cites W2046611929 @default.
• W2015410192 cites W2047535883 @default.
• W2015410192 cites W2047884170 @default.
• W2015410192 cites W2055557113 @default.
• W2015410192 cites W2055927100 @default.
• W2015410192 cites W2056389198 @default.
• W2015410192 cites W2056491004 @default.
• W2015410192 cites W2057827526 @default.
• W2015410192 cites W2059405665 @default.
• W2015410192 cites W2061633669 @default.
• W2015410192 cites W2062904839 @default.
• W2015410192 cites W2063324016 @default.
• W2015410192 cites W2064438779 @default.
• W2015410192 cites W2071599468 @default.
• W2015410192 cites W2072397199 @default.
• W2015410192 cites W2076304606 @default.
• W2015410192 cites W2081150698 @default.
• W2015410192 cites W2088571971 @default.
• W2015410192 cites W2091064369 @default.
• W2015410192 cites W2091531113 @default.
• W2015410192 cites W2092491372 @default.
• W2015410192 cites W2106095767 @default.
• W2015410192 cites W2113238381 @default.
• W2015410192 cites W2125694669 @default.
• W2015410192 cites W2125984741 @default.
• W2015410192 cites W2128752949 @default.
• W2015410192 cites W2132802598 @default.
• W2015410192 cites W2134736026 @default.
• W2015410192 cites W2137493887 @default.
• W2015410192 cites W2137918636 @default.
• W2015410192 cites W2143034003 @default.
• W2015410192 cites W2148943593 @default.
• W2015410192 cites W2150393596 @default.
• W2015410192 cites W2157492530 @default.
• W2015410192 cites W2160765861 @default.
• W2015410192 cites W2162507760 @default.
• W2015410192 cites W2164400093 @default.
• W2015410192 cites W2164948164 @default.
• W2015410192 cites W2169473035 @default.
• W2015410192 cites W2172149172 @default.
• W2015410192 cites W4232387401 @default.
• W2015410192 cites W1985636884 @default.
• W2015410192 doi "https://doi.org/10.1371/journal.pone.0028666" @default.
• W2015410192 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3253083" @default.
• W2015410192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22238580" @default.
• W2015410192 hasPublicationYear "2012" @default.
• W2015410192 type Work @default.
• W2015410192 sameAs 2015410192 @default.
• W2015410192 citedByCount "87" @default.
• W2015410192 countsByYear W20154101922012 @default.
• W2015410192 countsByYear W20154101922013 @default.
• W2015410192 countsByYear W20154101922014 @default.
• W2015410192 countsByYear W20154101922015 @default.
• W2015410192 countsByYear W20154101922016 @default.

• next