FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015411289> ?p ?o ?g. }

• W2015411289 endingPage "10" @default.
• W2015411289 startingPage "1" @default.
• W2015411289 abstract "THP-1 2A9, a subclone of the monocytoid cell line THP-1 and known to be exquisitely sensitive to LPS, was tested for TNF production following triggering by excess doses of TLR ligands. TLR2, TLR4 and TLR5 agonists, but neither TLR3 nor TLR9 agonists, induced TNF production. When used at lower concentrations, priming by calcitriol strongly influenced the sensitivity of cells to LPS and different TLR2 triggers (lipoteichoic acid (LTA), trispalmitoyl-cysteyl-seryl-lysyl-lysyl-lysyl-lysine (Pam3Cys) and peptidoglycan (PGN)). Priming by calcitriol failed to modulate TLR2 and TLR4 mRNA and cell surface expression of these receptors. TNF signals elicited by TLR2 agonists were blocked by the TLR-specific antibody 2392. CD14-specific antibodies showed variable effects. CD14-specific antibodies inhibited TNF induction by LTA. High concentrations partially inhibited TNF induction by Pam3Cys. The same antibodies failed to inhibit TNF induction by PGN. Thus, THP-1 2A9 cells respond by TNF production to some, but not all TLR agonists, and the wide variety of putative TLR2 agonists interact to variable degrees also with other cell-surface-expressed binding sites such as CD14. THP-1 2A9 cells might provide a model by which to investigate in more detail the interaction of pathogen-associated molecular patterns and monocytoid cell-surface-expressed pattern recognition receptors." @default.
• W2015411289 created "2016-06-24" @default.
• W2015411289 creator A5016130634 @default.
• W2015411289 creator A5022007647 @default.
• W2015411289 creator A5070462517 @default.
• W2015411289 creator A5081807240 @default.
• W2015411289 date "2006-06-01" @default.
• W2015411289 modified "2023-10-10" @default.
• W2015411289 title "Human monocytoid cells as a model to study Toll-like receptor-mediated activation" @default.
• W2015411289 cites W1496461152 @default.
• W2015411289 cites W1502575492 @default.
• W2015411289 cites W1519633296 @default.
• W2015411289 cites W1534699340 @default.
• W2015411289 cites W1646413467 @default.
• W2015411289 cites W1655860314 @default.
• W2015411289 cites W1881367260 @default.
• W2015411289 cites W1979132095 @default.
• W2015411289 cites W1983493780 @default.
• W2015411289 cites W1996790111 @default.
• W2015411289 cites W1999331168 @default.
• W2015411289 cites W2008152503 @default.
• W2015411289 cites W2016862474 @default.
• W2015411289 cites W2019737761 @default.
• W2015411289 cites W2020969008 @default.
• W2015411289 cites W2023309048 @default.
• W2015411289 cites W2027089681 @default.
• W2015411289 cites W2028795263 @default.
• W2015411289 cites W2029157767 @default.
• W2015411289 cites W2036722100 @default.
• W2015411289 cites W2045384882 @default.
• W2015411289 cites W2045392502 @default.
• W2015411289 cites W2069981713 @default.
• W2015411289 cites W2076361525 @default.
• W2015411289 cites W2076613161 @default.
• W2015411289 cites W2087803640 @default.
• W2015411289 cites W2090670039 @default.
• W2015411289 cites W2095833996 @default.
• W2015411289 cites W2104904748 @default.
• W2015411289 cites W2109609116 @default.
• W2015411289 cites W2113116950 @default.
• W2015411289 cites W2116766330 @default.
• W2015411289 cites W2129319296 @default.
• W2015411289 cites W2130946949 @default.
• W2015411289 cites W2143498880 @default.
• W2015411289 cites W2168452238 @default.
• W2015411289 cites W2172043071 @default.
• W2015411289 doi "https://doi.org/10.1016/j.jim.2005.07.026" @default.
• W2015411289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16720029" @default.
• W2015411289 hasPublicationYear "2006" @default.
• W2015411289 type Work @default.
• W2015411289 sameAs 2015411289 @default.
• W2015411289 citedByCount "22" @default.
• W2015411289 countsByYear W20154112892012 @default.
• W2015411289 countsByYear W20154112892013 @default.
• W2015411289 countsByYear W20154112892014 @default.
• W2015411289 countsByYear W20154112892019 @default.
• W2015411289 countsByYear W20154112892021 @default.
• W2015411289 countsByYear W20154112892023 @default.
• W2015411289 crossrefType "journal-article" @default.
• W2015411289 hasAuthorship W2015411289A5016130634 @default.
• W2015411289 hasAuthorship W2015411289A5022007647 @default.
• W2015411289 hasAuthorship W2015411289A5070462517 @default.
• W2015411289 hasAuthorship W2015411289A5081807240 @default.
• W2015411289 hasConcept C136449434 @default.
• W2015411289 hasConcept C153911025 @default.
• W2015411289 hasConcept C170493617 @default.
• W2015411289 hasConcept C185592680 @default.
• W2015411289 hasConcept C2776070231 @default.
• W2015411289 hasConcept C2776709828 @default.
• W2015411289 hasConcept C2778513237 @default.
• W2015411289 hasConcept C2781236682 @default.
• W2015411289 hasConcept C55493867 @default.
• W2015411289 hasConcept C86803240 @default.
• W2015411289 hasConcept C95444343 @default.
• W2015411289 hasConceptScore W2015411289C136449434 @default.
• W2015411289 hasConceptScore W2015411289C153911025 @default.
• W2015411289 hasConceptScore W2015411289C170493617 @default.
• W2015411289 hasConceptScore W2015411289C185592680 @default.
• W2015411289 hasConceptScore W2015411289C2776070231 @default.
• W2015411289 hasConceptScore W2015411289C2776709828 @default.
• W2015411289 hasConceptScore W2015411289C2778513237 @default.
• W2015411289 hasConceptScore W2015411289C2781236682 @default.
• W2015411289 hasConceptScore W2015411289C55493867 @default.
• W2015411289 hasConceptScore W2015411289C86803240 @default.
• W2015411289 hasConceptScore W2015411289C95444343 @default.
• W2015411289 hasIssue "1-2" @default.
• W2015411289 hasLocation W20154112891 @default.
• W2015411289 hasLocation W20154112892 @default.
• W2015411289 hasOpenAccess W2015411289 @default.
• W2015411289 hasPrimaryLocation W20154112891 @default.
• W2015411289 hasRelatedWork W1503713311 @default.
• W2015411289 hasRelatedWork W1897355343 @default.
• W2015411289 hasRelatedWork W2000049307 @default.
• W2015411289 hasRelatedWork W2123043501 @default.
• W2015411289 hasRelatedWork W2127018220 @default.
• W2015411289 hasRelatedWork W2154862758 @default.
• W2015411289 hasRelatedWork W2154970317 @default.
• W2015411289 hasRelatedWork W2156445477 @default.

• next