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- W2015419033 abstract "We have observed delayed-type hypersensitivity (DTH) reactions in immunized mice challenged subcutaneously with class I-binding peptides related to rejection antigens recognized by cytotoxic T lymphocytes on mutagenized (tum-) variants of mastocytoma P815. As observed by skin test in virally infected mice challenged with viral peptides, the intrafootpad injection of tum- peptides resulted in a dose-dependent DTH that peaked at approximately 24 h. The response was mediated by CD8+ cells and could be induced by previous vaccination of mice with live tumor cells, intrasplenic deposition of the eliciting peptide, or adoptive transfer with peptide-pulsed syngeneic dendritic cells. These sensitization procedures resulted in an immunologically specific footpad reaction detectable for up to 2-6 months after priming. The evaluation by DTH in cancer patients of long-lived CD8+ anti-tumor T cell responses following local challenge with tumor-specific peptides may be of great interest in human immunotherapy trials involving immunization against identified tumor antigens." @default.
- W2015419033 created "2016-06-24" @default.
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- W2015419033 date "1994-06-01" @default.
- W2015419033 modified "2023-10-13" @default.
- W2015419033 title "Use of a skin test assay to determine tumor-specific CD8+ T cell reactivity" @default.
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- W2015419033 doi "https://doi.org/10.1002/eji.1830240631" @default.
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