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- W2015429211 abstract "Degenerative changes in the substantia nigra and ventral tegmental area were investigated in 104 cases of Alzheimer9s disease and 13 cases of Down9s syndrome. Frequencies of tangles in three groups of patients with Alzheimer9s disease were 86%, 44% and 46% (54% overall) respectively. About half of those with tangles, but no Lewy bodies, had excess nigral cell loss, and 16% had moderate or severe neuronal fallout, but none had a Parkinsonian syndrome. Cases with nigral tangles were younger, tended to have more hippocampal and cortical tangles and plaques, and lower activities of cortical choline acetyltransferase. In most cases of Alzheimer9s disease degeneration in nigral and tegmental areas was greater than controls, and tangles were evenly distributed. All the cases of Down9s syndrome had tangles in the nigra and eight showed mild cell loss. Mild degenerative changes accompanied by tangles in the substantia nigra and ventral tegmental area are common in Alzheimer9s disease, but severe cell loss is rare. When a Parkinsonian syndrome occurs in Alzheimer9s disease it is likely to be due to Lewy body pathology." @default.
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- W2015429211 date "1989-02-01" @default.
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- W2015429211 title "The substantia nigra and ventral tegmental area in Alzheimer's disease and Down's syndrome." @default.
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- W2015429211 doi "https://doi.org/10.1136/jnnp.52.2.193" @default.
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